The aim of this longitudinal study was to assess the frequency of nonreversible airflow obstruction (NRAO) among adults with moderate to severe asthma, and to compare the decline of forced expiratory volume in one second (FEV1) in asthmatics with reversible and nonreversible airflow obstruction. Ninety-two (31 males) life-long nonsmokers with asthma participated in a 10-yr follow-up study; mean...

Daytime sleepiness and neural cardiac modulation in sleep-related breathing disorders. Viral wheezing is virus specific and not just host specific To the Editors: In a recent issue of the European Respiratory Journal, STRIPPOLI et al. [1] reported their interesting findings on exclusive viral wheezing versus allergic wheezing in a large population-based, prospectively followed cohort including ...

Sputum induction has been used to study asthma in children since the first description of the technique in 1992 [1]. Since then, w20 reports (five reviews) have appeared in the literature describing sputum induction in children with airways disease. In general, sputum induction in children of w6 yrs is safe and has a satisfactory success rate. Approximately 500 children have been studied by spu...

This study examined age- and sex-associated variation in peak oxygen consumption (VO2) of young male and female distance runners from an allometric scaling perspective. Subjects were from two separate studies of 9- to 19-yr-old distance runners from the mid-Michigan area, one conducted between 1982 and 1986 (Young Runners Study I, YRS I) and the other in 1999-2000 (Young Runners Study II, YRS I...

Recent studies suggest that inhaled corticosteroids can adversely affect bone metabolism. The objective of this study was to evaluate the importance of these adverse effects in a case-control study. Bone mineral density (BMD) was measured in 48 asthmatic adults (15 males and 33 females) treated with inhaled steroids (beclomethasone or budesonide) and in 48 gender and age-matched healthy subject...

The purpose of this study was to analyze foot pressure distribution of shape memory materials functional insole. Comfort is an important aspect for footwear and insole. Footwear and insole comfort has an influence on injury [1,2]. The development of new materials is considered as the important point for manufacturing functional insole [3,4]. Ten healthy male (mean height: 174.7±4.0 cm, mean bod...

Increased sympathetic nerve activity may play an important role in the pathogenesis of essential hypertension. It is well known that both dietary sodium intake and age influence the plasma norepinephrine (NE) concentration. The present study was undertaken to evaluate the effects of age on sympathetic nerve activity in patients with essential hypertension and normal control subjects under low-,...

OBJECTIVE We sought to study and procure reference values for weight-related maximum isometric grip force (MIGF), maximum voluntary force in relation to body weight (Fmvrel) and peak whole body stiffness (pKwb) in multiple one-legged hopping (m1LH) in childhood. METHODS We examined 868 children and adolescents (436 female) aged 3 to 19 yrs. Weight related results are reported as multiples of ...

STUDY OBJECTIVES To perform a within-subject analysis of the changes in absolute and normalized rates of non-rapid eye movement (NREM) delta power production across daytime naps and baseline sleep, specifically to determine whether these rates change linearly or exponentially. DESIGN Subjects were studied in a 2-day protocol after screening for sleep disorders. The first night was a baseline ...