On the basis of biologically active 3-aminopyridine-2(1H)-ones, authors carried out chemical modification into derivatives corresponding monothiooxamides for first time. It has been shown that 3-aminopyridin-2(1H)-oneenter transamidation reactions with hydrazine-hydrate and are further cyclized under action chloroacetyl chloride conjugated 1,3,4-thiadizole derivatives.

reaction between aromatic aldehydes and 3–methyl-1-phenyl-2-pyrazoline-5-one catalyzed by nano-sio2/hclo4 in water under reflux provided a simple and efficient route for the synthesis of 4-((5-hydroxy-3-methyl-1-phenyl-1h-pyrazol-4-yl)(aryl)methyl)-3-methyl-1-phenyl-1h-pyrazol-5-ol derivatives in high yields.

Decatungstodivanadogermanic acid (H6GeW10V2O40.22H2O) was used as a green heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones from one-pot three-component cyclocondensation reaction of a β-ketoester, an aldehyde and urea/thiourea under solvent-free conditions is reported. This method provides an efficient and much improved modification of the original Biginelli reaction...

Decatungstodivanadogermanic acid (H6GeW10V2O40.22H2O) was used as a green heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones from one-pot three-component cyclocondensation reaction of a β-ketoester, an aldehyde and urea/thiourea under solvent-free conditions is reported. This method provides an efficient and much improved modification of the original Biginelli reaction...

The purpose of this study was to synthesize substituted 3,4-dihydropyrimidin-2(1H)ones (DHP) and to evaluate them for their antibacterial and antifungal activities. These compounds were synthesized by cyclocondensation reaction between substituted aromatic aldehyde i.e.,p-anisaldehyde, active methylene compounds (ethyl acetoacetate/acetylacetone), urea in the presence of CuCl2.2H2O and few drop...