In this randomized, double-blind, placebo controlled study, the safety of therapeutic (675 mg) and supra-therapeutic (2,700 mg) doses of nitazoxanide was evaluated in accordance with the ICH E14 guidelines. Fifty six (56) subjects participated in four treatment periods and received single doses of nitazoxanide 675 mg, nitazoxanide 2,700 mg, moxifloxacin 400 mg, or placebo. For 675 mg nitazoxani...

Several studies have established that pseudogene mRNAs can work as competing endogenous RNAs and, when deregulated, play a key role in the onset of human neoplasias. Recently, we have isolated two HMGA1 pseudogenes, HMGA1P6 and HMGA1P7. These pseudogenes have a critical role in cancer progression, acting as micro RNA (miRNA) sponges for HMGA1 and other cancer-related genes. HMGA1 pseudogenes we...

Suboptimal placental growth and development are the underlying cause of many pregnancy complications. No treatments are available, primarily due to the risk of causing fetal teratogenicity. microRNAs (miRNAs) are short, non-coding RNA sequences that regulate multiple downstream genes; miR-145 and miR675 have previously been identified as negative regulators of placental growth. In this proof of...

the nutritive and anti-nutritive components of raw detarium microcarpum seed meals (dsm), and its’ impact on performance and blood constituents were investigated in broilers. day-old broilers (n=225) were randomly assigned to five treatments at graded levels of 0, 5, 10, 15 and 20% dsm in a completely randomized design. feed and water were given ad libitum till56 days. the analyzed dsm containe...

Abstract Background Despite increasing knowledge of the pathogenesis muscle ageing, molecular mechanisms are poorly understood. Based on an expression analysis biopsies from older Caucasian men, we undertook in‐depth long non‐coding RNA, H19 , to identify that may contribute loss mass with age. Methods We carried out transcriptome vastus lateralis 40 healthy men aged 68–76 years Hertfordshire S...

This paper introduces an accurate yet analytically simple approximation to the stance dynamics of the SpringLoaded Inverted Pendulum (SLIP) model in the presence of non-negligible damping and non-symmetric stance trajectories. Since the SLIP model has long been established as an accurate descriptive model for running behaviors, its careful analysis is instrumental in the design of successful lo...