نتایج جستجو برای: 3101 and 1062
تعداد نتایج: 16827332 فیلتر نتایج به سال:
Background: Trop-2 is a well validated oncology therapeutic target. DB-1305 an antibody drug conjugate designed by conjugating anti-Trop-2 with novel topoisomerase I inhibitor P1021 via enzymatically cleavable tetrapeptide linker. Material and Methods: To characterize the payload P1021, thorough studies were performed including in vitro functional assays, vivo efficacy PK/PD murine CDX models, ...
BACKGROUND The adverse impact on doctors' health of constant organizational change in healthcare is well established. AIMS To investigate the change in self-referral rates to a doctors' mental health service, and associated morbidity over a decade. METHODS All doctors attending a doctors' mental health service between 1 January 2002 and 31 December 2011 were asked to complete the Clinical O...
The RET tyrosine kinase is a functional receptor for neurotrophic ligands of the glial cell line-derived neurotrophic factor (GDNF) family. Loss of function of RET is associated with congenital megacolon or Hirschsprung's disease, whereas germ-line point mutations causing RET activation are responsible for multiple endocrine neoplasia type 2 (MEN2A, MEN2B, and familial medullary thyroid carcino...
Genome-wide linkage studies have defined a broad susceptibility region for late-onset Alzheimer's disease on chromosome 12, which contains the Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) gene, a coreceptor for Wnt signaling. Here, we report the association between common LRP6 variants and late-onset Alzheimer's disease in a multicenter case-control series as well as in a large fam...
GASTÓN SCHLOTTHAUER∗,§, MARÍA EUGENIA TORRES∗,¶, 7 HUGO L. RUFINER†,‖ and PATRICK FLANDRIN‡,// ∗Lab. Signals and Nonlinear Dynamics, Applied Research group 9 on Signal Processing and Pattern Recognition (ARSiPRe) Facultad de Ingenieŕıa, Universidad Nacional de Entre Rı́os 11 Ruta 11 Km 10 Oro Verde, Entre Rı́os 3101, Argentina ∗National Council of Scientific and Technical Research (CONICET) 13 †L...
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