The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used ge...

The radial scar (RS) or complex sclerosing lesion (CSL) of the breast represents a management dilemma on diagnosis at breast core needle biopsy because of the risk of associated malignancy identified only upon surgical excision. To determine our experience, we retrospectively reviewed core needle biopsies performed at the Darlene G. Cass Breast Imaging Center from 2006 to 2011, identifying 67 p...

The industrial washing of corn grain during its milling generates a residue known as “corn steep liquor (CSL)”. This is rich in amino acids, carbohydrates, vitamins, and mineral nutrients that can stimulate the vegetative growth when applied to plants. However, mode action this product not yet known. work involved foliar root application pepper plants, at dose 5 mL L−1, two CSL products (CSL-H ...

Notch is a phylogenetically conserved transmembrane receptor that is required for many aspects of animal development. Upon ligand stimulation, a fragment of Notch is released proteolytically and enters the nucleus to form a complex with the DNA-binding protein CSL (CBF1/Suppressor of Hairless/Lag1) and activate transcription of Notch-CSL target genes. The physical structure of the Notch-CSL com...

Disclosure: David Parr has received honoraria for advising CSL Behring and Grifols (formerly Talecris), in addition to sponsorship from AstraZeneca and Boehringer Ingelheim. Emer Reeves and Niels Seersholm have no competing interests to disclose; however, both have received honoraria for this educational activity funded by CSL Behring. Kenneth R. Chapman has received compensation for consulting...

We study a spin-1 single flavor color superconducting phase which results from a color-spin locking (CSL) interaction in two-flavor quark matter. This phase is particularly interesting for compact star cooling applications since the CSL phase may survive under charge neutrality constraints implying a mismatch between upand down-quark chemical potentials which can destroy the scalar diquark cond...

For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996 [1, 2]. Their proof can be turned into an approximation algorithm with worse than exponential complexity. In 2000, Baier, Haverkort, Hermanns and Katoen [4, 5] presented an efficient polyno...

Cancer-associated fibroblasts (CAFs) are important for tumor initiation and promotion. CSL, a transcriptional repressor and Notch mediator, suppresses CAF activation. Like CSL, ATF3, a stress-responsive transcriptional repressor, is down-modulated in skin cancer stromal cells, and Atf3 knockout mice develop aggressive chemically induced skin tumors with enhanced CAF activation. Even at low basa...

Programs for the analysis of pathological voice data have been presented for the last few decades. Computerized Speech Lab (CSL) has been recognized as a standard in the field of pathological voice analysis. PRAAT is a new open program which is constantly being improved almost every week. CSL gives the “Voice disorders database” which was produced by Massachusetts Eye and Ear Infirmary. In this...