1. Lung function was studied in fifty-six symptom-free asthmatic subjects after the inhalation of urea, an agent not previously used for asthma provocation. The effects of urea were compared with those produced by the inhalation of methacholine and of isoprenaline. 2. After urea ventilatory capacity was impaired in 68% of subjects and improved in 16%. This response was a relatively constant phe...

Home hemodialysis is the most cost-effective form of dialysis and is associated with the lowest mortality. Home hemodialysis patients are usually highly motivated, independent, and actively employed. Because of the minimal supervision they require and the fact that they are not in a controlled environment, it is easy to overlook the measurement of their dialysis adequacy. We studied 6 home hemo...

In the title compound, C(16)H(13)N(5)O(2)S, the five non-H atoms of the urea linkage adopt a planar configuration owing to the presence of an intra-molecular N-H⋯O hydrogen bond. The maximum deviation from planarity is 0.022 (2) Å. The thia-diazole and pyridine heterocyclic rings are close to being coplanar, with a dihedral angle of 6.7 (2)° between their mean planes. Inter-molecular N-H⋯O hydr...

The mono-, di-, tri-, and tetranucleotides resulting from complete ribonuclease T1 (1) digests of ribonucleic acid have been described in preceding papers (2, 3). More recently, buffers containing 7 M urea (4) were shown to facilitate greatly the fractionation of oligonucleotides according to chain length at neutral pH (5). Rechromatography in urea-containing buffers at pH 2.7 was found to reso...