نتایج جستجو برای: 2r csai

تعداد نتایج: 4897  

Journal: :Chemical & pharmaceutical bulletin 2001
S S Kang J S Kim K H Son H P Kim H W Chang

A mixture of cerebrosides, called poke-weed cerebrosides, was purified from Phytolaccae Radix (Phytolaccaceae) and characterized as 1-O-beta-D-glucopyranosides of phytosphingosine type ceramides comprised of a common long chain base (2S,3S,4R,8Z)-2-amino-8-octadecene-1,3,4-triol and fatty acids. The fatty acyl chain of ceramide moieties was determined as (2R)-2-hydroxypentacosanoic acid, (2R)-2...

2008
JAAP KOREVAAR

For k > 1, r 6= 0 and large x, let π 2r (x) denote the number of prime pairs (p, p+2r) with p ≤ x. By the Bateman–Horn conjecture the function π 2r(x) should be asymptotic to (2/k)C k 2rli2(x), with certain specific constants C 2r . Heuristic arguments lead to the conjecture that these constants have mean value one, just like the Hardy–Littlewood constants C2r for prime pairs (p, p + 2r). The c...

Journal: :Molecular endocrinology 2005
J A Koehler B Yusta D J Drucker

Glucagon-like peptide-2 (GLP-2) regulates proliferative and cytoprotective pathways in the intestine; however GLP-2 receptor (GLP-2R) signal transduction remains poorly understood, and cell lines that express the endogenous GLP-2R have not yet been isolated. We have now identified several expressed sequence tags from human cervical carcinoma cDNA libraries that correspond to GLP-2R nucleotide s...

2013
Noriaki Yoshida Miyo Oda Yoshiaki Kuroda Yuta Katayama Yoshiko Okikawa Taro Masunari Megumu Fujiwara Takashi Nishisaka Naomi Sasaki Yoshito Sadahira Keichiro Mihara Hideki Asaoku Hirotaka Matsui Masao Seto Akiro Kimura Koji Arihiro Akira Sakai

Elevated soluble interleukin-2 receptor (sIL-2R) in sera is observed in patients with malignant lymphoma (ML). Therefore, sIL-2R is commonly used as a diagnostic and prognostic marker for ML, but the mechanisms responsible for the increase in sIL-2R levels in patients with B-cell lymphomas have not yet been elucidated. We first hypothesized that lymphoma cells expressing IL-2R and some proteina...

2013
Tzu-Kai Lin Mao-Qiang Man Juan-Luis Santiago Kyungho Park Truus Roelandt Yuko Oda Melanie Hupe Debra Crumrine Hae-Jin Lee Maria Gschwandtner Jacob P. Thyssen Carles Trullas Erwin Tschachler Kenneth R. Feingold Peter M. Elias

Systemic antagonists of the histamine type 1 and 2 receptors (H1/2r) are widely used as anti-pruritics and central sedatives, but demonstrate only modest anti-inflammatory activity. Because many inflammatory dermatoses result from defects in cutaneous barrier function, and because keratinocytes express both Hr1 and Hr2, we hypothesized that H1/2r antagonists might be more effective if they were...

1997
Haruhiko Suzuki Gordon S. Duncan Hiroaki Takimoto

The interleukin-2 receptor b chain (IL-2R b ) is expressed on a variety of hematopoietic cell types, including natural killer (NK) cells and nonconventional T lymphocyte subsets such as intestinal intraepithelial lymphocytes (IEL). However, the importance of IL-2R b -mediated signaling in the growth and development of these cells has yet to be clearly established. We have investigated IEL and N...

2014
Anne Tournadre Jean-Jacques Dubost Martin Soubrier Marc Ruivard Pierre Souteyrand Jeannot Schmidt Pierre Clavelou Arlette Tridon Jean-Michel Ristori

OBJECTIVE To evaluate the clinical significance of serum soluble IL-2R (sIL-2R) in inflammatory myopathies. METHODS Serum sIL-2R and CK levels were determined in 27 patients with IM during periods of disease exacerbation and inactive disease and were compared to 20 healthy controls and 23 controls with noninflammatory elevated CK. The performance of sIL-2R and CK tests for assessing disease a...

Journal: :Chest 2003
Jan C Grutters Jean-Marc Fellrath Leontine Mulder Rob Janssen Jules M M van den Bosch Heleen van Velzen-Blad

OBJECTIVES To date, insufficient evidence is available to recommend serum soluble interleukin-2 receptor (sIL-2R) measurement as a routine test in the assessment of sarcoidosis. Therefore, we evaluated the clinical value of this test. DESIGN Forty-seven patients with sarcoidosis, all presenting with active disease, were included in the study. Initial serum sIL-2R levels were determined by enz...

Journal: :The European respiratory journal 1995
C H Chan C K Lai J C Leung A S Ho K N Lai

Soluble interleukin-2 receptor (sIL-2R) is a marker of T-lymphocyte activation. We have undertaken a study to examine the serum sIL-2R levels in patients with pulmonary tuberculosis (TB) and the changes following anti-TB chemotherapy. Forty four patients with pulmonary TB or tuberculous pleural effusion were recruited. Serum was collected from the patients before and at 1, 2, 4 and 6 months aft...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه محقق اردبیلی - دانشکده علوم پایه 1391

پپتیدها پتانسیل زیادی به عنوان دارو دارند ولی به دلایل مختلف مثل هضم توسط پروتئازها، انتقال کم از غشا و انعطاف پذیری بالا استفاده از آن ها محدودیت هایی دارد. برای جلوگیری از استفاده مقادیر بالای داروها، انتقال ویژه بافتی و کاهش اثرات جانبی آن ها، نیاز به سیستم های حامل دارورسانی احساس می گردد. بروینین- 2r ، پپتیدی 12 آمینواسیدی و یک ماده ی دفاعی غیر همولیتیک است؛ ساختاری آمفی پاتیک دارد، انت...

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