The soft-clustered vehicle-routing problem is a variant of the classical capacitated (CVRP) in which customers are partitioned into clusters and all same cluster must be served by vehicle. We introduce novel symmetric formulation clustering part modeled with an asymmetric sub-model. solve new model branch-and-cut algorithm exploiting some known valid inequalities for CVRP that can adapted. In a...

Pecin et al. (2016) introduced a “limited memory” technique that allows an efficient use of Rank-1 cuts in the Set Partitioning Formulation of Vehicle Routing Problems, motivating a deeper investigation of those cuts. This work presents a computational polyhedral study that determines the best possible sets of multipliers for cuts with up to 5 rows. Experiments with CVRP instances show that the...

From fruit bodies of the basidiomycete Hygrophorus eburneus (Bull.: Fr.) Fr. (Tricholomataceae) eight fatty acids (C16, C18) with γ-oxocrotonate partial structure could be isolated. Initial tests demonstrate their bactericidal and fungicidal activity. The structures of (2E,9E)-4-oxooctadeca2,9,17-trienoic acid (1), (2E,11Z)-4-oxooctadeca-2,11,17-trienoic acid (2), (E)-4-oxohexadeca-2,15dienoic ...

Ising machines can find optimum or quasi-optimum solutions of combinatorial optimization problems efficiently and effectively. It is known that, when a good initial solution given to an machine, we finally obtain closer the optimal solution. However, several cannot directly accept due its computational nature. In this paper, propose method give quasiinitial into that them. The proposed gives po...

In this paper, a deterministic heuristic method is developed for obtaining an initial solution to extremely large-scale capacitated vehicle routing problem (CVRP) having thousands of customers. The has three main objectives. First, it should be able withstand the computational and memory problems normally associated with CVRP. Secondly, outputs reasonably accurate have minimum number vehicles. ...

The MAP-2 isoform containing exon 13 (MAP-2e) is expressed in human fetal development as early as 15 gestational weeks and parallels oligodendrocyte maturation. MAP-2e is down-regulated following myelination and is expressed in few cells in the adult central nervous system (CNS). To determine whether CNS tumors express MAP-2e, we screened 122 archival, paraffin-embedded adult and pediatric tumo...

Capacitated Vehicle Routing Problem (CVRP) is among transportation problems that are of the foremost concerns in logistics. Ensuring an effective product distribution over a large distribution network while reducing the required costs represents the scope of the present work. A synergic and interactive environment of parallel meta-heuristics is developed using a generalized island model to deal...