Ras CAAX (C = cysteine, A = aliphatic amino acid, and X = any amino acid) peptidomimetic inhibitors of farnesyl protein transferase suppress Ras-dependent cell transformation by preventing farnesylation of the Ras oncoprotein. These compounds are potential anticancer agents for tumors associated with Ras mutations. The peptidomimetic FTI-254 was tested for Ras1-inhibiting activity in whole anim...

BACKGROUND Hepatitis C virus infection is now one the common infection in Pakistan. Patients are routinely screened by antibody assays. Objective of this study was to assess the viremia in patients labelled as anti-HCV positive by ELISA. METHODS It this retrospective study patients labelled as anti HCV positive by ELISA were assessed for HCV RNA by polymerase chain reaction. The 254 HCV posit...

The study analyses the phonological interference of phoneme pronunciation [q] by Sundanese and Javanese speakers compared with Arabic speakers. researchers used a descriptive comparative qualitative method. listened, took notes, documented voice recordings male students from ethnic groups when reading Qur'an to collect research data analyse it using Praat software version 6.2.13. From results r...

Photocycloaddition, Thymine, Azetidine, Cyclobutane Adducts Photochemical reactions of thymine linked to hypoxanthine or imidazole by a trimethylene chain were studied in aqueous solution. Irradiation (A = 254 nm) of thymine-hypoxanthine pair yielded two internal cycloadducts with azetidine and cyclobutane part structures. Sensitization and quenching experiments suggested that the excited singl...

Ultraviolet sources with output wavelengths or 254, 300, and 366 nm were compared for detection of ethidium bromide-DNA complexes in acrylamide gels. The 254and 300-nni sources were both much more sensitive than the 366-nni source. The 254-nni .source produced a great deal of photodamage, photonickingand photodimerization, and photobleaching, while the longer wavelength sources cause little dam...

Stream water samples were collected over a range of hydrologic and seasonal conditions at three forested watersheds in the northeastern USA. Samples were analyzed for dissolved total mercury (THg(d)), DOC concentration and DOC composition, and UV(254) absorbance across the three sites over different seasons and flow conditions. Pooling data from all sites, we found a strong positive correlation...

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High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F(254) plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation of ibuprofen and pseudoephedrine hydr...

Inherited and Secondary Thrombophilia Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2014 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.113.001943 2014;129:254-257 Circulation. http://circ.ahajournals.org/content/129/2/254 World Wide Web at: The onl...

The use of image enhancement for the visually impaired was flIst proposed by Peli ~d Peli in 1984. Today, the technology to implement image enhancement techniques in real-time exists. We tested the use of this technology in the reading of scrolled text. The purpose of this study was to determine if this enhancement algorithm would incre.ase impaired observers' ability to read scrolled text. T!l...