The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products staurosporine, K252a, rebeccamycin, and AT2433-A1, respectively. Here, we show that StaC and InkE, which mediate a net 4-electron oxidation, bind FAD with a micromolar K(d), whereas RebC and AtmC, which mediate a net 8-electron oxidation, bi...

The main mechanisms of percutaneous coronary intervention (PCI) with stent implantation are vessel expansion and plaque redistribution, and one of the major complications is dissection originating from the proximal or distal stent edge. Although angiographic criteria for a significant dissection have been published, the criteria for a significant intravascular ultrasound (IVUS)–detected stent e...

Os antibióticos são substâncias classificadas como contaminantes emergentes e uma preocupação constante devido aos efeitos deletério, ao meio ambiente ser humano, principalmente pelo desenvolvimento de microrganismos resistentes antibióticos. A tecnologia atual tratamento águas residuais não pode remover esgoto maneira eficiente e, portanto, novas tecnologias baixo custo necessárias. Neste trab...

Essential micronutrients are required for humans to sustain proper physiological body processes and a healthy health condition. Micronutrient deficiencies, such as iron, zinc, iodine, create global concerns people. Zinc iron deficiency frequent in chickpea growing regions across the world. Bio-fortification of pulse grains, especially with Fe Zn by agronomic bio-fortification, is simplest, most...

Meiosis I in males of the Dipteran $ciara coprophila results in the nonrandom distribution of maternally and paternally derived chromosome sets to the two division products. Based on an earlier study (Kubai, D. E 1982. J. Cell Biol. 93:655-669), I suggested that the meiosis I spindle does not play a direct role in the nonrandom sorting of chromosomes but that, instead, haploid sets are already ...

The prevalence of abiotic stresses hampers soil health and plant growth in most ecosystems. In this study, rice husk iron-enriched biochar (BC) was prepared its superiority terms nutrients enrichment, porosity different acidic functional group (O-H, C=O) relative to simple confirmed through scanning electron microscopic, X-ray fluorescence Fourier transform infrared analysis. To further evaluat...

Few studies have reported the association between body mass index (BMI) and outcome among Asian breast cancer patients. We analyzed data for 20,090 female invasive breast cancer patients who had been followed-up for a median period of 6.7 years entered in the National Clinical Database-Breast Cancer Registry between 2004 and 2006. We used mainly the WHO criteria for BMI (kg/m(2) ) categories; <...

BACKGROUND We performed an updated meta-analysis of randomized placebo-controlled trials testing memantine monotherapy for patients with Alzheimer's disease (AD). METHODS The meta-analysis included randomized controlled trials of memantine monotherapy for AD, omitting those in which patients were also administered a cholinesterase inhibitor. Cognitive function, activities of daily living, beh...