catabolite gene activator protein (CAP) I. Saturation and alanine-scanning mutagenesis. J. Mol. Biol. 243:595-602. 10.Rhodius, V.A., D.M. West, C.L. Webster, S.J.W. Busby, and N.J. Savery. 1997. Transcription activation at class II CRP-dependent promoters: the role of different activating regions. Nucleic Acids Res. 25:326-332. 11.Savery, N.J., G.S. Lloyd, M. Kainz, T. Gaal, W. Ross, R.H. Ebrig...

HLA-B27-restricted CTL responses to EBV are principally directed against two of the EBV nuclear Ags, EBNAs 3B and 3C. We have previously described a target epitope derived from EBNA 3C (residues 258-266, sequence RRIYDLIEL) that is immunodominant in the context of at least three different B27 subtypes, including B*2705 and B*2702. In this study, we show that this peptide binds well to B*2705 an...

Consider a semimartingale reflecting Brownian motion (SRBM) Z whose state space is the d-dimensional nonnegative orthant. The data for such a process are a drift vector θ , a nonsingular d × d covariance matrix ", and a d × d reflection matrix R that specifies the boundary behavior of Z. We say that Z is positive recurrent, or stable, if the expected time to hit an arbitrary open neighborhood o...

This study tested a time-domain spectral enhancement algorithm that was recently proposed by Turicchia and Sarpeshkar [IEEE Trans. Speech Audio Proc. 13, 243-253 (2005)]. The algorithm uses a filter bank, with each filter channel comprising broadly tuned amplitude compression, followed by more narrowly tuned expansion (companding). Normal-hearing listeners were tested in their ability to recogn...

Luis A.M. Carrascosa Group TEP-243, Departamento de Química-Física, Facultad de Ciencias (Universidad de Cádiz), Puerto Real (Cadiz), Spain, [email protected] Dario S. Facio Group TEP-243, Departamento de Química-Física, Facultad de Ciencias (Universidad de Cádiz), Puerto Real (Cadiz), Spain, [email protected] Maria J. Mosquera Group TEP-243, Departamento de Química-Física, F...

Purpose: The retinoic acid receptors are expressed from early stages of development in the diverse tissues that make up the vertebrate eye. Their loss has subtle effects on eye development. We adapted sensitive quantitative trait locus (QTL) mapping methods to assess consequences of inactivating alleles of the alpha and beta receptors, Rara and Rarb, on eye and retinal development. Rara is of p...