PURPOSE To investigate the safety and potential efficacy of ranibizumab for prevention of radiation complications in patients treated with proton irradiation for choroidal melanoma. METHODS Forty patients with tumors located within 2 disc diameters of the optic nerve and/or macula were enrolled in this open-label study. Participants received ranibizumab 0.5 mg or 1.0 mg at tumor localization ...

These studies are primarily concerned with recovery from sublethal actinomycin D or radiation damage as measured by joint lethality of the two treatments separated by an interval of 1 hr to 4 days. In mice given actinomycin D and challenged with radiation, the high mortality attributable to joint treatment decreased steadily between the 6-hr and the 3-day challenge. On the other hand, in mice g...

the currently reactor wreckage in fukushima raised the following important questions: is our knowledge of the possible dangers of ionizing radiation sufficient to warrant special action? what is the role of the medical community in technical radiation accidents from windscale to fukushima? what is the role of the medical community in terrorist radiation attacks? are we prepared for those challe...

this study assessed the optimum water need of pepper (capsicum annuum l. cv. california wonder) and the critical irrigation level to be applied in order to achieve a reasonable economic yield in water shortage conditions. in a controlled field experiment involving five different treatments, seasonal evapotranspiration for pepper fluctuated from 89 mm in the severe stress treatment (i0.00) to 1,...

We previously isolated several clones that were closely-related genetically from a human colorectal tumor (HCT116) cell line. These clones displayed significantly different X-radiation response phenotypes. In this paper, we investigated how a single dose of X-radiation modulated the transcriptomic profiles of either the radiation-resistant (HCT116Clone2_XRR) or the radiation-sensitive (HCT116Cl...

Injury to the central nervous system (CNS) by ionizing radiation may be a consequence of damage to the vascular endothelium. Recent studies showed that radiation-induced apoptosis of endothelial cells in vitro and in the lung in vivo is mediated by the lipid second messenger ceramide via activation of acid sphingomyelinase (ASM). This apoptotic response to radiation can be inhibited by basic fi...

Introduction: Despite the extensive use of ionizing radiation in diagnosis and therapeutic procedures, development of radio-protector agents is important in modulating normal tissue damages. Hesperidin(HES) is a Flavanone glycoside, belonging to the Flavonoid family in human diet abundantly and noted for its many beneficial effects. The aim of present study was investigated to ...

The effects of acute, multiple, and chronic exposure of hairless mice to ultraviolet radiation (UVR) on induction of epidermal ornithine decarboxylase (ODC) (EC 4.1.1.17) activity were investigated. Acute UVR exposure results in a biphasic time course of induction of epidermal ODC activity. Enzyme activity maxima occur at 3 and 24 h postirradiation. The biphasic time course is observed in two d...