The crystal structure of the title compound, C31H45BrO5·CH2Cl2, prepared in six steps from diosgenin, confirmed that the configurations of the stereogenic centers, positions 20S and 25R, remain unchanged during the reaction. The six-membered A, B and C rings have chair conformations. The five-membered ring D has an envelope conformation (with the methyl-substituted C atom fused to ring C as the...

In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) tumour cells (A431, A549, MCF-7, NCI-H1975). particular, compound 4d 3-flu...

Three papers in the Journal this month examine the impact on service use of particular service developments and patient/illness characteristics. Williams et al (pp. 480–485) compared patterns of service use, including hospital admission rates, before and after the introduction of a triage admission system in one large innercity mental health organisation. Overall, little difference was found be...

Several papers in the BJPsych this month address issues arising from the overlap or comorbidity between mental and physical ill health. In a UK sample of individuals with affective disorders, Forty et al (pp. 465–472) found significantly increased rates of several medical illnesses among those with bipolar and unipolar disorder compared with controls. Among those with affective disorder, migrai...

In the present work, we have planned a new magnetically recoverable nanocatalyst. The obtained nanocatalyst designated as Fe3O4@SiO2@DOPisatin-Ni (II) was characterized by FTIR, XRD, SEM, EDAX, VSM, AAS and TGA techniques. It was found that Fe3O4@SiO2@DOPisatin-Ni (II) successfully catalyses the synthesis of 2,3-dihydroquinazolin-4(1H)-ones, polyhydroquinoline and 5-substituted 1H-tetrazoles in...

Two papers in the Journal this month examine patterns of prescribing practice. With established clinical guidelines for the management of individuals with treatment-resistant schizophrenia in mind, Howes et al (pp. 481–485) reviewed prescribing practices prior to commencement of clozapine for a sample of patients managed within one mental health service. The authors found evidence of a signific...

We have previously reported that, depending on their activation status, mouse γδ T cells can either enhance or inhibit the activity of IL-17(+) autoreactive T cells in experimental autoimmune uveitis. In this study, we showed that γδ T cells in naive C57BL/6 (B6) mouse do not express the IL-23R, whereas in immunized mice, it is expressed on >50% of γδ T cells. In vitro studies showed that IL-23...