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Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) gene to CD34+ BM precursor cells using gammaretroviral vectors. While 9 of 10 patients were successfully treated, 4 of the 9 developed T cell leukemia 31-68 months after gene therapy. In 2 of these cases, blast cells contained activating vector insertions ...
Medullary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET proto-oncogene. DNA analysis for germl...
A substantial fraction of neuroblastomas found by mass screening have been suggested to regress spontaneously because of the high incidence of infantile neuroblastomas in the screening population. In this study, 70 neuroblastomas were analyzed for expression of proto-oncogenes related to neuronal differentiation to clarify the biological significance of proto-oncogene expression in the screenin...
Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced rodent tumors. The majority of activated proto-oncogenes found in these tumor...
For over a century the text of the Phaistos Disk remained an enigma without a convincing translation. This paper presents a novel semi-automatic translation method that uses for the first time a recently discovered connection between the Phaistos Disk symbols and other ancient scripts, including the Old Hungarian alphabet. The connection between the Phaistos Disk script and the Old Hungarian al...
ABSTRACT We report the first detection in JK = 10–00 rotational transition line of CH3D towards three Class 0/I proto-brown dwarfs (proto-BDs) from IRAM 30-m observations. Assuming a temperature 25 K, abundances (relative to H2) are range (2.3–14.5) × 10−7. The CH4 derived and assuming DCO+/HCO+ ratios (0.05–4.8) 10−5. gas-phase formation via CH2D+ is enhanced at high densities 108–1010 cm−3 ou...
The defective acute leukemia viruses avian myeloblastosis virus (AMV) and E26 virus each contain an inserted cellular sequence related to the same highly conserved cellular gene, proto-amv. The oncogenes of these two retroviruses differ from this cellular proto-oncogene in gene structure, transcript structure, and gene product. The product of the AMV oncogene (myb) is a 48,000 Mr protein, p48my...
We evaluated the utility of the Japanese version of the Checklist for Autism in Toddlers for predicting pervasive developmental disorders (PDD) among 2-year-old children in clinical settings. Confirmed diagnosis revealed that the pass rate on four items (social interest, proto-imperative pointing, proto-declarative pointing and joint-attention) was significantly lower in 52 PDD children than in...
The Earth formed through accretion of planetesimals in 1–100 million years. Planetesimal impacts induce degassing, melting, and vaporization during accretion. The impact degassing, as well as the gravitational capture of the surrounding solar nebula gas, formed the proto-atmosphere on a growing Earth. The impact of heating and the blanketing effect of the proto-atmosphere resulted in the meltin...
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