Parambalath Narendran Ashitha designed the cover image and, along with colleagues at Central Power Research Institute, wrote accompanying article on how successful deployment of nanofillers in hightemperature vulcanizing silicone rubber matrix requires chemical surface treatments. The authors utilized a facile technique employing use an in-situ modification filler surfaces. In this work, import...

"When I joined the Willow Run Laboratories of the University of Michigan in 1959, my colleagues were investigating how coherent optical processing systems could be used to obtain maps from synthetic-aperture, side-looking radar systems. This work would eventually lead to the important discovery of off-axis holography. I was interested in solving a different problem—that of using opt ica l proce...

The cover by Thanh-Duong Nguyen shows the development of novel chemically bonded tribomaterials based on polyamides, irradiated polytetrafluoroethylene, and oil molecules. materials are formed through a twostep process reactive-extrusion. This article presents compound's morphology, crystallization behavior, mechanical properties. It was found that PA12-(Z7321) offered best coupling degree is m...

In the article from Shuling Zhang and Youmei Ma, Silica nanoparticles with a refractive index matching poly (propylene carbonate) (PPC) diameter smaller than visible light wavelength were chosen to prepare transparent PPC/silica nanocomposites enhanced properties using simple melt compounding method. Details can be found in their article. DOI: 10.1002/app.51513

Multiple Ag peptides (MAPs) containing eight proteolipid protein (PLP)(139-151) peptides arranged around a dendrimeric branched lysine core were used to influence the expression and development of relapsing experimental allergic encephalomyelitis (EAE) in SJL mice. The PLP(139-151) MAPs were very efficient agents in preventing the development of clinical disease when administered after immuniza...

MiRNAs may promote or inhibit tumor recurrence and drug resistance. MiR-139-5p is reportedly downregulated in colorectal cancer patient samples, but it is unknown whether and how miR-139-5p regulates drug resistance. Cancer stem cells (CSCs) are postulated to be important promoters of multiple drug resistance (MDR). In this study, we established a MDR cell model which strongly expressed the CSC...

We have previously shown that naive SJL (H-2(s)) mice, which are highly susceptible to myelin proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE), have a very high frequency (1/20,000 CD4 T cells) of PLP(139-151)-reactive T cells in the naive repertoire. In this study, we examine the function of this endogenous PLP(139-151)-reactive repertoire in vivo and find that...