ADRENERGIC beta-receptors are responsible for the cardiac effects of the sympathetic nervous system (Ahlquist, 1948). Pronethalol (Black and Stephenson, 1962) first proved to be an effective beta-receptor blocking agent with little sympathomimetic activity. Limited clinical trials suggested that pronethalol was of value in angina (Dornhorst and Robinson, 1962; Alleyne and colleagues, 1963; Barn...

Ames, R. P., Borkowski, A. J., Sicinski, A. M., and Laragh, J. H. (1965). 7. clin. Invest., 44, 1171. Bartter, F. C., Pronove, P., Gill, J. R., jun., and MacCardle, R. C. (1962). Amer. 7. Med., 33, 811. Boucher, R., Veyrat, R., Champlain, J. de, and Genest, J. (1964). Canad. med. Ass. 7., 90, 194. Brown, J. J., Davies, D. L., Lever, A. F., and Robertson, J. I. S. (1964). 7. Physiol. (Lond.), 17...

The clinical use of direct current shock in the management of cardiac arrhythmias (Lown, Amarasingham, and Neuman, 1962) has been amply confirmed by many other workers (O'Brien, Resnekov, and McDonald, 1964; Oram et al., 1964; Morris et al., 1964b). The length of time that sinus rhythm persists after the electrical conversion of chronic arrhythmias is often disappointingly short, even when quin...

Changes in haematocrit in patients with acute myocardial infarction are the subject of several reports. Burch and DePasquale (1962) and DePasquale and Burch (1963) suggested that the peripheral venous haematocrit was raised in acute myocardial infarction. This was not confirmed by subsequent studies (Conley et al., 1964; Vuopio and Eisalo, 1964) but has recently been supported (Stables et al., ...

The radiological changes in the peripheral joints of patients with psoriatic arthritis differ from those in cases of rheumatoid arthritis (Wright, 1961; Lassus, Mustakallio, and Laine, 1964; Sherman, 1952; di Vittorio, Viara, and Chiaudano, 1965; Tesarek, 1966; Sigler, 1966). Changes are also seen in the spine and sacro-iliac joints (Wright, 1961; Lassus and others, 1964; Sherman, 1952; Duthie,...

3 Jacob, T. MI., E. Ohtsuka, M. W. Moon, S. A. Narang, and H. G. Khorana, Federation Proc., 23, 531 (1964). 4Jacob, T. M., and H. G. Khorana, Abstr. Sixth Internat. Congr. Biochem., 1, 62 (1964). 5 Most of the abbreviations are as in current use in J. Biol. Chem.: d-(TTC)3 is abbreviation for the nonanucleotide d-TpTpCpTpTpCpTpTpC, bearing no phosphomonoester end group, and similarly, d-(TTC)2 ...