was found to be slightly different from other HEVs and included a putative ORF (ORF4) of 552 nt that overlapped with ORF1 (online Technical Appendix Figure). A similar pattern of genome organization was observed for both FRHEVs. Phylogenetic analysis of the complete genomes clearly showed that FRHEV was separated from genotype 1–4 HEVs and clustered with rat HEV (Figure). Similar phylogenetic c...

BACKGROUND AND OBJECTIVE Clostridium difficile NAP1/ribotype 027 is associated with severe disease and high mortality rates. Our aim was to determine the prevalence of NAP1/ribotype 027 among C. difficile isolates in a tertiary care hospital, and review the main clinical data. METHODS We included 106 stool samples from 106 patients. Samples were tested for A&B toxins and were cultured on CCFA...

BACKGROUND An outbreak of Clostridium difficile ribotype 027 infection (CDI) occurred at an university hospital, involving 19 departments. To determine what hospital-associated factors drove the outbreak of this particular strain we performed a case-control study. METHODS Cases (n = 79), diagnosed with CDI due to C. difficile ribotype 027 were matched for age and treating medical specialty to...

Prostate-specific membrane antigen (PSMA)-targeted radiotherapy of prostate cancer (PCa) has emerged recently as a promising approach to the treatment of disseminated disease. A small number of ligands have been evaluated in patients, and although early tumor response is encouraging, relapse rate is high and these compounds localize to the parotid, salivary, and lacrimal glands as well as to th...

Abstract We present a method to determine the internal quantum deficiency (IQD) of predictable efficient detector (PQED) based on measured photocurrent dependence bias voltage and 3D simulation model charge carrier recombination losses. The silicon photodiodes includes wafer doping concentration, fixed SiO 2 layer, bulk lifetime carriers surface velocity as fitted parameters. With only one set ...

This study aims to formulate policies for regulating asset forfeiture from corruption crimes in ius constitutum or positive law Indonesia and constituendum future Indonesia. The method used this is normative legal research method. results show that the formulative policy of still regulated general broadly Criminal Code, Law No. 20 2001 jo. 31 1999 on Eradication Corruption 8 2010 Prevention Mon...

PURPOSE To determine whether mTORC2 and rapamycin-insensitive (RI)-mTORC1 complexes are present in acute myeloid leukemia (AML) cells and to examine the effects of dual mTORC2/mTORC1 inhibition on primitive AML leukemic progenitors. EXPERIMENTAL DESIGN Combinations of different experimental approaches were used, including immunoblotting to detect phosphorylated/activated forms of elements of ...

Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges from mild diarrhea to life threatening PMC. Recently, a highly virulent strain of C. difficile polymerase chain reaction ribotype 027 was found in North America, Europe, and Japan. A 52-yr-old woman with anti-tuberculosis medication and neurogenic bl...