Fragments of cDNA representing greater than 99% of the entire genome of wild-type hepatitis A virus (HAV) strain AGM-27, isolated from an African green monkey, were obtained by the polymerase chain reaction and sequenced. Comparison with other HAV isolates revealed differences in the predicted amino acid sequence in functionally critical parts of the genome. Comparison of the biological propert...

BACKGROUND The malaria parasite Plasmodium falciparum EBA-175 binds its receptor sialic acids on glycophorin A when invading erythrocytes. The receptor-binding region (RII) contains two cysteine-rich domains with similar cysteine motifs (F1 and F2). Functional relationships between F1 and F2 domains and characterization of EBA-175 were studied using specific monoclonal antibodies (mAbs) against...

Disrupting erythrocyte invasion by Plasmodium falciparum is an attractive approach to combat malaria. P. falciparum EBA-175 (PfEBA-175) engages the host receptor Glycophorin A (GpA) during invasion and is a leading vaccine candidate. Antibodies that recognize PfEBA-175 can prevent parasite growth, although not all antibodies are inhibitory. Here, using x-ray crystallography, small-angle x-ray s...

We recently purified the rat liver hyaluronan receptor for endocytosis (HARE) and found abundant expression of 175- and approximately 300-kDa HARE species in sinusoidal endothelial cells of the liver, spleen, and lymph nodes. We report herein the first cloning and functional expression of the rat 175-kDa HARE. Peptide sequences were obtained from the purified 175-kDa HARE, and degenerate oligon...

When culturing the pileitrama of young fruit bodies of the two mycoparasitic agarics, Asterophora lycoperdoides (Bull.: Fr.) Ditmar and A. parasitica (Bull.: Fr.) Singer, two tremelloid yeasts were detected (Laaser et al., 1988, 1989; Prillinger, 1987a). The term tremelloid was suggested by Oberwinkler (Laaser et al., 1988; Oberwinkler pers. comm.) for budding yeasts having a cup-shaped parenth...

Background: Uterine fibroids are a common condition in Senegal and often symptomatic. Our study aims to determine the epidemiological profile, clarify diagnostic aspects evaluate surgical management of patients with uterine fibroids. Patients Method: We carried out retrospective descriptive over period 30 months, from August 1, 2017 January 31, 2020, concerning all who underwent surgery for tre...