In many turtles the temperature during the middle of incubation determines the gonadal sex of the hatchling. Sex steroid hormones have been implicated in temperature-dependent sex determination in the red-eared slider turtle, Trachemys scripta; nonaromatizable androgens are involved in male sex determination and estrogens and aromatizable androgens in female sex determination. Administration of...

PURPOSE To evaluate the effects of 17-β-estradiol on hyperosmolar stress-induced proinflammatory cytokine production of interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) in SV40-immortalized human corneal epithelial cells (hCECs) and the regulatory effects of the mitogen-activated protein kinase (MAPK) signaling pathways in this process. METHODS SV40 hCECs cultured in normal o...

BACKGROUND Previous studies have established that estrogen is capable of accelerating cutaneous wound healing through multiple mechanisms, one of which involves affecting keratinocytes biological properties, such as migration, proliferation, etc. This study aims to reveal the underlying molecular mechanisms of estrogen promoting epidermal keratinocytes proliferation. Method & RESULTS We f...

Hatzoglou, C., K. I. Gourgoulianis, A. Hatzoglou, E. Castanas, and P. A. Molyvdas. Rapid effects of 17 -estradiol and progesterone on sheep visceral and parietal pleurae via a nitric oxide pathway. J Appl Physiol 93: 752–758, 2002. First published February 1, 2002; 10.1152/japplphysiol. 00425.2001.—We investigated the effects of 17 -estradiol and progesterone on transepithelial electrical resis...

Reports of reproductive abnormalities in the American alligator from Lake Apopka, Florida, have been linked to a spill of DDT and other pesticides suspected of having hormonelike activity. To determine whether environmental chemicals had the potential to function as exogenous hormones in the American alligator, we examined the ability of chemicals to bind the estrogen receptor (aER) and progest...

INTRODUCTION The purpose of the study is to compare the effects of genistein, estradiol, estradiol/progesterone combination on the bone mineral density and biomechanical properties of ovariectomized rats' bone. METHODS 50 female adult Sprague-Dawley rats were divided into five groups. Bilaterally ovaeriectomy were performed in all groups except the sham-operated group. Groups were a sham-oper...

Isoflavones are phytoestrogens which have estrogen-like activity in animals and humans with structure similar to 17-β-estradiol and capable of binding to estrogen receptors (ERs).This experiment was conducted to demonstrate the effect of isoflavones on estradiol concentration in blood and its influence on the productive performances in ISA Brown laying hens fed with supplemented feed with large...