Introduction: Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as wel...

The impact of exogenic testosterone (T): 1.5 and 3.0 mg/kg.bw) and 19-nortestosterone 17-decanoate (ND): 1.5 and 7.5 mg/kg.bw) in castrated male rats was evaluated based on: (a) weight increase of the androgen target tissues, respecting the Hershberger methodology; (b) the 17α and β-testosterone, 17 α and β-estradiol and 17 α and β-nortestosterone levels using the GC-MS/MS technique; and (c) ob...

T he influence of estrogen on blood pressure is complicated and sometimes contradictory. Premenopausal women have a lower incidence of hypertension, but recent clinical trials suggest that postmenopausal hormone replacement therapy does not necessarily decrease the risk of cardiovascular disease. Sexually dimorphic hypertension is evident in multiple animal models, yet only some indicate a crit...

BACKGROUND Bacterial toxin-antitoxin systems usually comprise of a pair of genes encoding a stable toxin and its cognate labile antitoxin and are located in the chromosome or in plasmids of several bacterial species. Chromosomally-encoded toxin-antitoxin systems are involved in bacterial stress responses and activation of the toxins usually leads to cell death or dormancy. Overexpression of the...

O objetivo deste estudo foi observar os efeitos da reposição de 17 β-estradiol na microbiota fecal gatas castradas. Amostras individuais fezes frescas foram colhidas e armazenadas a -80°C. Foi realizado o sequenciamento das regiões V3/V4 do gene 16S rRNA análise bioinformática. A razão Firmicutes/Bacteriodetes menor no grupo que recebeu estrogênica em comparação ao SHAM (P = 0,005). índice Jacc...

Background: Endometriosis is a chronic hormone-dependent inflammatory disease determined by the presence of foci endometrial tissue outside uterine cavity. Genetic factors occupy leading position in etiopathogenesis this disease. With endometriosis, there pronounced hormonal imbalance sex hormones both lesion and body sick woman as whole. The aim study:To study associations polymorphism hormone...