BACKGROUND Oestrogenic contaminants are widespread in the aquatic environment and have been shown to induce adverse effects in both wildlife (most notably in fish) and humans, raising international concern. Available detecting and testing systems are limited in their capacity to elucidate oestrogen signalling pathways and physiological impacts. Here we developed a transient expression assay to ...

BACKGROUND Endocrine disruptors are exogenous substance, interfere with the endocrine system, and disrupt hormonal functions. However, the effect of endocrine disruptors in different species has not yet been elucidated. Therefore, we investigated the possible effects of 17ß-estradiol (E2), progesterone (P4), genistein (GEN) and 4-tert-octylphenol (OP), on capacitation and the acrosome reaction ...

Pesticides are increasingly used worldwide to enable increase production of higher quality crops and the elimination of some diseases. Unfortunately, these chemicals intended to cause harm or death to certain pests are also toxic to humans. Although this is evidenced by many epidemiological studies carried out in developed countries, less is still known about the associated degradation of healt...

Endokrin wirksame Substanzen (EDC, endocrine-disrupting chemicals) in Abwässern bekommen zunehmend mehr Aufmerksamkeit, da die schädliche Wirkung für das Hormonsystem von Lebewesen bestätigt wurde. Das kostengünstige Gestein Alginit als neuartiges Adsorbens ist aufgrund der guten Abreicherungsraten gegenüber EDC neben herkömmlich genutzten Aktivkohle ein Reinigungsverfahren 4. Reinigungsstufe g...

MALIGNANT GLIOMA. Experimental studies with an estrogen-linked cytostatic. Eva von Schoultz, Department of Oncology, University of Umeå, S-901 85 Umeå, Sweden. Malignant gliomas are the most common primary brain tumors in adults. Patients with these highly malignant tumors have an extremely poor prognosis. The situation with a highly proliferative tumor in a non-proliferating tissue should favo...

(6,7-3H] Estrone (E) and [6,7-3H]estradiol-17ß (~) have been synthesized by reduction of 6-dehydroestrone and 6-dehydroestradiol with tritium gas. Tritiated E and E2 were administered by oral gavage to female rats and to male and female hamsters on a dose Ievel of about 300 ~glkg (54 mCilkg). After 8 h, the liver was excised from the rats; liver and kidneys were taken from the hamsters. DNA was...

Pregnancy was successfully established in an agonadal woman using donated oocytes and in vitro fertilization. The oocyte donor had previously failed to provide an in vivo fertilized pre-embryo to the infertile couple despite several attempts at uterine lavage. Mark V. Sauer, MD, Women’s Hospital, Room L-946, 1240 North Mission Road, Los Angeles, CA 90033 (USA) Introduction Successful impregnati...