Epothilones have demonstrated promising potential for oncology applications but suffer from a narrow therapeutic window. Epothilone D stabilizes microtubules leading to apoptosis, is active against multidrug-resistant cells, and is efficacious in animal tumor models despite lack of stability in rodent plasma. Clinical development was terminated in phase II due to dose limiting toxicities near t...

I N T R O D U C T I O N . . 142 IN VIVO D I G E S T I O N I N SIMPLE-STOMACH A N I M A L S . . 142 S T O M A C H . . . 143 SMALL INTESTINE . . 143 H I N D G U T . . 143 FACTORS I N F L U E N C I N G DIGESTIBILITY I N V I V O . . 144 I N VITRO M E T H O D S FOR E S T I M A T I N G D I G E S T I B I L I T Y . . . 145 D I A L Y S I S CELL METHOD . . 145 Objective . . 145 Principle . . 145 Methods....

TOP Objective: To assess changes in speech intelligibility as a function of signal processing strategy and as a function of time for one of the first two Ineraid patients in the United States fitted with a continuous interleaved sampling (CIS) signal processor. Design: In Experiment 1, the patient was fitted with a CIS processor and measures of speech intelligibility were taken over a period of...