OBJECTIVES I-131 therapy for differentiated thyroid cancer (DTC) could induce adverse effects. The purpose of this study was to report and analyze symptoms after I-131 treatment within the hospitalization and present relevant medical intervention. METHODS I-131 doses ranging from 3.7 to 9.25 GBq (100-250 mCi) were administrated for thyroid remnant ablation or treating DTC metastases. 117 pati...

BACKGROUND Use of recombinant human thyrotropin increases the thyroid radioiodine (iodine 131 [(131)I]) uptake and may have a role in the context of (131)I therapy of benign goiter. METHODS In a double-blind, placebo-controlled trial, 57 patients with nodular nontoxic goiter (51 women and 6 men) were randomized to receive either 0.3 mg of recombinant human thyrotropin (n = 28) or placebo (n =...

UNLABELLED Nuclear medicine technology assumes responsibility for examination-specific patient preparation procedures. This requires a clear understanding of the possible effects of medications on the outcome of examinations. There is evidence that common over-the-counter drugs, histamine 1 (H1) and histamine 2 (H2) receptor blockers and proton pump inhibitors, may directly or indirectly affect...

conclusions: this study provides detailed information and case samples of radiodine contamination artifacts and non-physiological, non-metastatic extra-thyroidal i-131 accumulation in whole-body i-131 imaging. introduction: radioactive iodine has been used for more than 50 years for the treatment of thyroid diseases. differentiated thyroid cancers have the ability to trap iodine. therefore, rad...

In a recent report (1), List, Telegadas, and Ferber take issue with my earlier conclusion (2) that vented underground tests in Nevada were the probable sources for the repeated occurrences of iodine-131 fallout in midwestern United States during May 1962. In doing so they provide no evidence to establish that the underground shots in question were contained, but they suggest that precipitation ...

S009-131, a coumarin-chalcone hybrid, had been shown to possess anti-proliferative and anti-tumour effect by triggering apoptosis. In this report, we investigated role of DNA damage signalling pathway in S009-131 induced cancer cell death. Here we show that S009-131 causes DNA damage by potential binding to the minor groove which led to the phosphorylation and activation of ATM and DNA-PK, but ...

INTRODUCTION The influence of demographic and clinical factors on the outcome of (131)I therapy in hyperthyroid patients has been examined, based on a retrospective evaluation of results obtained in patients submitted to (131)I treatment at the Department of Nuclear Medicine and Oncological Endocrinology, Medical University of Lodz (Province Hospital, Zgierz). The goal of the study was to analy...

Retention of iodine in the thyroid gland is the result of renal excretion and transport of iodine to thyroid cells. Both processes are affected by furosemide. The aim of our study was to test whether furosemide influenced radioiodine-131 ((131)I) retention in the thyroid gland of living mice. Our methods were as follows: After 15 days of low-iodine diet, 19 Swiss mice received an intra-peritone...