OBJECTIVES To describe the population pharmacokinetics of oral amoxicillin and to compare the PTA of current dosing regimens. METHODS Two groups, each with 14 healthy male volunteers, received oral amoxicillin/clavulanic acid tablets on two separate days 1 week apart. One group received 875/125 mg twice daily and 500/125 mg three times daily and the other group 500/125 mg twice daily and 250/...

the medicinal plants have been used since ancient times and are still utilized by the majority of the population. hence, it is essential to investigate the cytotoxic and genotoxic effects of these plants. the aim of this study was to evaluate the toxic effects of fennel seeds decoctions, traditionally used in iran as an herbal remedy.  the cytotoxicity was tested in vitro using allium cepa l. r...

OBJECTIVES Our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([(125)I]PYK) is promising for the evaluation of the epidermal growth factor receptor (EGFR) status and prediction of gefitinib treatment of non-small cell lung cancer. EGFR is over-expressed and mutated also in glioblastoma. In the present study, the e...

Ovarian cancer continues to be a major health threat for women. The American Cancer Society estimates that in the United States in 1998, 25 400 new cases will be diagnosed and 14 500 women will die as a result of this disease (1). Most of these cancers are epithelial in origin, as germ cell tumors of the ovary represent only ;5% of the total. Approximately 70% of epithelial ovarian cancers will...

Overexpression of neuropeptide Y (NPY) and its receptor system has been reported in various types of cancers. NPY Y5 receptor (Y5R) has been implicated in cell growth and angiogenesis. However, the role of Y5R in breast cancer is unknown. To identify the role of Y5R in breast cancer, we screened several breast cancer cell lines to examine the expression of Y5R and its function in breast cancer....

Background: Monoclonal antibodies (mAbs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. Humoral immune response of immunized animals largely depends on the nature of antigen and the immunization technique. Polysaccharides and heavily-glycosylated proteins are very elusive target...

Background: Ovarian cancer is the fifth leading cause of death from malignancy in women. CD4 +CD25+FoxP3+ regulatory T (Treg) cells are a subset of T lymphocytes with great inhibitory impact on immune response. Objectives: To investigate the percentage of CD4 +CD25+FoxP3+ regulatory T cells in the peripheral blood of the Iranian patients with epithelial ovarian cancer compared to healthy women ...

Radiocarbon Dates: J. B. Arnold and W. F. Libby..................................... 111 Technical Papers Clotting Time and Reaction Velocity in the Interaction of Bovine Fibrinogen and Thrombin: David F. Waugh and Betty J. Livingstone .121 Radiocarbon Age Measurements and Fossil Man in Mexico .-gelmut de Terra .124 Lipase from Molds Grown on Oil Seeds: C. V. Ramakrishna* and B. N. Banerjee .12...

Curcumin, a natural polyphenolic flavonoid extracted from the rhizome of Curcuma longa L., was shown to possess superior potency to resensitize methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics. Previous studies have shown the synergistic activity of curcumin with β-lactam and quinolone antibiotics. Further, to understand the anti-MRSA mechanism of curcumin, we investigated the ...

background: monoclonal antibodies (mabs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. humoral immune response of immunized animals largely depends on the nature of antigen and the immunization technique. polysaccharides and heavily-glycosylated proteins are very elusive target...