To determine whether alterations in the "reverse" or "conversion" pathway for putrescine formation were involved in the induction of colonic tumors by 1,2-dimethylhydrazine, male albino rats of the Sherman strain were given injections s.c. of this agent (20 mg/kg body weight/week) or diluent for 5, 10, 15, and/or 26 weeks. Animals were sacrificed at each of these time periods and polyamine leve...

Epidemiological and experimental studies indicate that environmental and dietary factors are probably important determinants of colorectal cancer (CRC). Among dietary factors alcohol intake has been shown to be associated with an increased risk of CRC (1). A large number of epidemiologic studies have examined the possible association of beer and ethanol ingestion on CRC risk. As a result, some ...

cinogen (3, 31). Tumors were also produced in the duo denum, small intestine, liver, and kidney by 1,2-dimethyl hydrazine (3, 10, 13, 31). The distribution of tumors de pended on the dosage and method of application, but even a single injection resulted in the formation of some tumors in the colon and kidney (3, 10). The mechanism by which 1,2-dimethylhydrazine exerts its carcinogenic action ha...

Abstract Background Colorectal cancer is considered a potential causative agent of morbidity and death, making it particularly dangerous malignancy. The current study aims to assess the efficacy ferulic acid (FA) attenuate harmful side effect 5-fluorouracil (5FU) in colon tissues induced by 1,2-dimethylhydrazine (DMH). Results Regarding male Wistar-albino rats ( Rattus norvegicus ), combined FA...

GaInNAs/GaAs multiple quantum well (MQW) structures for long wavelength emission were grown by atmospheric pressure metalorganic vapor phase epitaxy using trimethylgallium, trimethylindium, tertiarybutylarsine and dimethylhydrazine precursors. The dependence of the N concentration and the emission wavelength on the In concentration was investigated. The longest wavelengths were obtained with In...

Intestinal tumors were induced by repeated subcutaneous injection of 1,2-dimethylhydrazine in Donryu strain rats for 28 weeks. A streptococcal preparation, OK-432 was administered at different times of the tumor induction_ Between the OK-432 treated and the untreated groups no significant difference was observed in the incidence of intestinal tumors, the total number of tumors per rat, the loca...

We have performed this study to investigate the modulatory effect of thymoquinone (TQ), the Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats. Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of en...

In recent decades, there has been increasing interest in the use of herbs to maintain human health, many growing in the Southern and Eastern Asian countries. One example, pericarps of Garcinia mangostana (GM), called mangosteen, have been in use for hundreds of years as a traditional herbal medicine for a variety of purposes, including treatment of skin infections and wounds (Mahabusarakam, 198...