The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation by sequencing at a level that should allow the genome-wide detection of most variants with frequencies as low as 1%. However, in the major histocompatibility complex (MHC), only the top 10 most frequent haplotypes are in the 1% frequency range whereas thousands of haplotypes are present at lower ...

The 1000 Genomes Project created a valuable, worldwide reference for human genetic variation. Common uses of the 1000 Genomes dataset include genotype imputation supporting Genome-wide Association Studies, mapping expression Quantitative Trait Loci, filtering non-pathogenic variants from exome, whole genome and cancer genome sequencing projects, and genetic analysis of population structure and ...

The giant radar/radio astronomy dish near Arecibo, Puerto Rico, was conceived by William E. Gordon in early 1958 as a back-scattering radar system to measure the density and temperature of the Earth’s ionosphere up to a few thousand kilometers. Gordon calculated the required size of the antenna by using the Thomson crosssection for scattering by the electrons, and assuming that the elementary s...

Improved survival of very pre-term infants is a result of advances in obstetric and neonatal medicine. To provide relevant data for a Northern Ireland population group, we evaluated mortality and morbidity of extremely low birthweight (ELBW; < 1000 g) infants from a tertiary referral neonatal unit. Seventy-seven ELBW infants were admitted on the first day of life during the period April 1990 to...

the family of high-speed Ethernet technologies. It extends the operating speed of the world's most deployed LAN to 1 billion bits per second while maintaining compatibility with the installed base of 10 Mbps and 100 Mbps Ethernet equipment. T he installed base for Ethernet ranges from PCs and servers to printers , test equipment, telephone switches, cable TV set-top boxes, process control syste...

Social-Networking Websites (SNWs) are rapidly becoming a central media for social exchange. A basic question is how well are people able to get to know each other through these websites? In this study, we explore characteristics of the profile photographs and their association with impression agreement. Using a specially designed social networking website (http://www.YouJustGetMe.com), we exami...

In this paper we demonstrate an accurate, efficient, and parallelizable optimization algorithm for the layout of hundreds, then 1000, turbines. It is modular and therefore allows different wake effect models to be incorporated. Its computational cost is a relation which depends upon how many candidate layouts it investigates and the complexity of its wake loss calculation. We demonstrate how we...

Control biochemical and hematologic data were gathered for 1017 healthy submariners who ranged in age from 19.5 to 43.5 years. Means, standard deviation, and frequency distribution are presented for 24 whole blood and serum variables and, where appropriate, for 11 urinary variables. After statistical separation of the effects of aging and length of submarine service, it has been determined that...