Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. Accordingly, 3-nitropropionic acid (3-NP) has been found to effectively produce HD-like symptoms. Luehea divaricata (L. divaricata), popularly known in Brazil as "açoita-cavalo," may act as a neuroprotective agent in vitro and in vivo. We evaluated the hypothesis that the aqueous extract of L. divaricata could prevent...

Metformin lowers blood pressure in humans and in experimental animal models. To determine the mechanism of acute metformin-induced hypotension, we measured changes in mean arterial pressure (MAP) and heart rate (HR) during metformin alone (0, 10, 50, 100 mg/kg i.v.; n = 10) and during concomitant alpha adrenergic (phentolamine, 5 mg/kg; n = 5), beta adrenergic (propranolol, 3 mg/kg; n = 6), mus...

lead is an ubiquitous environmental toxin that induces a broad range of physiological biochemical, and behavioral dysfunctions. in this study, we examined the pathologic effects of lead acetate in nmri mouse ovarian tissue and the protective role of antioxidant l-cysteine, against the induced damage. we used lead acetate at a dose of 10 mg/kg, and l-cysteine at a dose of 200 mg/kg. both drugs w...

synthetic lhrha or its superactive analogues stimulate gth release. it shows an overlap in the biological activity of lhrha and gnrh in many teleost species. the aim of the present study was to investigate the effects of lhrha2, metoclopramide and chlorpromazine on hpg axis and plasma levels of ght ii. luteinizing hormone releasing hormone analogue 2 (lhrha2) (3 mg/kg) with dopamine antagonis’s...

Background: Cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. Hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. The aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats. Methods: ...

Lethal effects of trinitrotoluene (TNT) to juvenile sheepshead minnows (JSHM) (Cyprinodon variegatus) were assessed in ten-day water exposures. Ten-day median lethal concentrations (LC50s) were 2.3 and 2.5 mg L(-1), the 10-d median lethal residue value (LR50) was 26.1 micromol kg(-1) wet weight (ww), and bioconcentration factors (BCFs) ranged from 0.7 to 2.4 L kg(-1). The lethal effects of TNT ...

The goals of this study were to explore the characteristics nitrogen (N) absorption and utilisation chilli peppers (Capsicum annuum L.), improve rate nitrogen, provide a theoretical basis for scientific fertilisation. In experiment, pepper cv. Huoyanjiaowang was used as material, potted sand cultures field randomised block experiments conducted effects fertilisation different forms on photosynt...

INTRODUCTION We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. METHODS We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior test ...

Toltrazuril 5% suspension (Baycox, Bayer Canada, Ontario, Canada) was administered to six adult horses followed by blood collection and assay to determine the concentration of toltrazuril and its principal metabolites, toltrazuril sulfone and toltrazuril sulfoxide. From this data, the maximum concentration (C(max)), elimination half-life (T 1/2), and mean residence times of the plasma were dete...

High dose metoclopramide infusions (10 mg/kg) were administered to nineteen patients with bronchial carcinoma who were receiving intravenous cyclophosphamide as single agent chemotherapy. Considerable interindividual variability in metoclopramide disposition was observed. Mean clearance was 0.33 +/- 0.13 (s.d.) l h-1 kg-1, mean volume of distribution at steady state was 3.8 +/- 1.2 (s.d.) l/kg ...