conclusions these results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of hbv infection and susceptibility to hbv infection. results persistent hbv infection was associated with il-10-1082 ag (p = 0.001) and gg (p = 0.004) genotypes and g (p = 0.000) allele. il-10-819 t/c and -592 a/c genotype and allele frequencies did not show any correlation with the ...

By enabling a tight control of cell excitation, optogenetics is a powerful approach to study the function of neurons and neural circuits. With its transparent body, a fully mapped nervous system, easily quantifiable behaviors and many available genetic tools, Caenorhabditis elegans is an extremely well-suited model to decipher the functioning logic of the nervous system with optogenetics. Our g...

Interleukin-10 (IL-10) selectively inhibited lipopolysaccharide (LPS)-induced chemoattractant cytokine gene expression: levels of IP-10 mRNA were markedly suppressed in IL-10-treated mouse peritoneal macrophages, whereas the expression of the RANTES mRNA was only modestly reduced. IL-10 inhibited IP-10 mRNA accumulation by reducing IP-10 gene transcription as demonstrated by nuclear run-on anal...

Several genes encoding for different cytokines may play crucial roles in host susceptibility to tuberculosis (TB), since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphism. The association of the cytokine gene polymorphisms with the development of TB was investigated in this study. DNA samples were obtained from a Turkish population of 81 pat...

immune responses play critical roles in the leishmaniasis eradication. il-10 is a key regulator of immune responses, and the polymorphisms within its promoter region are associated with alteration in its expression. therefore, this study was designed to examine the correlation between polymorphism at the -1082 position of the il-10 gene and visceral leishmaniasis (vl).the il-10 -1082 polymorphi...