beta-Catenin can promote adhesion at the cell cortex and mediate Wnt signaling in the nucleus. We show that, in Caenorhabditis elegans, both WRM-1/beta-catenin and LIT-1 kinase localize to the anterior cell cortex during asymmetric cell division but to the nucleus of the posterior daughter afterward. Both the cortical and nuclear localizations are regulated by Wnts and are apparently coupled. W...

Background & Aim:The main aim of this study was stabilizing D. Sophia beverage and reduce its sedimentation rate. Experimental: Xanthan and Carboxy methyl cellulose gums have been used in three levels (0.05, .01 and .02 gr/lit) and mixture of Guar-xanthan and carboxymethyl cellulose (each .1 g/l) and extracted dried gum from D. Sophia in (1, 2 an...

Glucocorticoid receptor (GR) transcription is driven by alternative promoters to produce different exon 1 mRNA variants. CpG methylation on GR promoters profoundly affects GR transcription. GR in hippocampus is critical for energy homeostasis and stress responses, yet it remains unclear whether hippocampal expression of GR exon 1 mRNA variants and the methylation status of GR promoters differ b...

BACKGROUND Mice sensitized to ovalbumin develop allergic airway disease (AAD) with short-term aerosol challenge; however, airway inflammation resolves with long-term aerosol challenge, referred to as local inhalational tolerance (LIT). METHODS We sought to determine if resolution of airway inflammation correlated with increases in lymphocyte subsets in local lung compartments, including putat...

The last few years have seen a rising interest in the problem of synthesizing systems from temporal logic specifications. One major contributor to this is the recent work of Piterman et al., which showed how polynomial time synthesis could be achieved for a class of LTL specifications that is large enough and expressive enough to cover an extensive number of complex, real-world, applications (d...

The main focus of this article is to explore and investigate the fundamental constraints that should be at the basis of algorithm development in intelligent audio production systems. Through mix analysis and grounded theory strategies, a best-practices framework on the craft of mixing is sought out. Findings, while not to be taken as dogmatic, give a clear indication of preferred implementation...

This paper considers the problem of assumptions refinement in the context of unrealizable specifications for reactive systems. We propose a new counterstrategy-guided synthesis approach for GR(1) specifications based on Craig’s interpolants. Our interpolation-based method identifies causes for unrealizability and computes assumptions that directly target unrealizable cores, without the need for...

The idea of automatic synthesis of reactive programs starting from temporal logic (LTL) specifications is quite old, but was commonly thought to be infeasible due to the known double exponential complexity of the problem. However, new ideas have recently renewed the interest in LTL synthesis: One major new contribution in this area is the recent work of Piterman et al. who showed how polynomial...