نتایج جستجو برای: 1 sfrp

تعداد نتایج: 2752679  

2015
Shuanhu Zhou

Stem cell function decline during ageing can involve both cell intrinsic and extrinsic mechanisms. Bone and blood formation are intertwined in bone marrow, therefore haematopoietic cells and bone cells could be extrinsic factors for each other. In this study, we assessed the paracrine effects of extrinsic factors from haematopoietic cells on human mesenchymal stem cells (MSCs). Our data showed ...

Journal: :Development 2011
Pilar Esteve Africa Sandonìs Carmen Ibañez Akihiko Shimono Isabel Guerrero Paola Bovolenta

Secreted frizzled-related proteins (Sfrps) are considered Wnt signalling antagonists but recent studies have shown that specific family members enhance Wnt diffusion and thus positively modulate Wnt signalling. Whether this is a general and physiological property of all Sfrps remains unexplored. It is equally unclear whether disruption of Sfrp expression interferes with developmental events med...

Journal: :Mechanisms of Development 2002
Julia v. Frowein Kenneth Campbell Magdalena Götz

Patterning of the chick telencephalon has been debated, especially in regard to a ventral (subpallial) or dorsal (pallial) nature of the dorsal ventricular ridge (DVR). Here we report the expression patterns of chick homologues of molecules known to be involved in telencephalic patterning in other vertebrate species. We show here that the transcription factors Ngn1, Ngn2, Cash1, Gsh2 and the se...

Journal: :Molecular human reproduction 2011
Ettie Maman Yuval Yung Berta Cohen Sarah Konopnicki Mariabeatrice Dal Canto Rubens Fadini Hannah Kanety Alon Kedem Jehoshua Dor Ariel Hourvitz

Follicular development and ovulation are major processes in the reproductive system. Understanding their complexity is important to female fertility treatments and the control of reproductive processes. Wnt signaling pathway components were shown to be involved in reproduction in animal models. The secreted frizzled-related protein-4 (sFRP4), a potential modulator of Wnt4 signaling pathway, was...

2016
Qihua Yang Tao Huang Guoliang Ye Bojun Wang Xinjun Zhang

Methylation of secreted frizzled-related protein genes (SFRP) associated with the Wnt signaling pathway has previously been reported. However, the diagnostic role of SFRP methylation in colorectal cancer (CRC) remains unclear. A systematic search was performed to identify eligible articles for analysis. The pooled OR showed that SFRP1, SFRP2, SFRP4 and SFRP5 methylation was significantly higher...

Journal: :Annals of the New York Academy of Sciences 2006
Toshio Matsumoto Masahiro Abe

Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. MM cells enhance bone resorption by triggering a coordinated increase in RANK ligand and decrease in osteoprotegerin in the bone marrow. Macrophage inflammatory protein (MIP)-1alpha and (MIP)-1beta are secreted by MM cells, and play a major role in the enha...

Journal: :Human molecular genetics 1999
J T Chang N Esumi K Moore Y Li S Zhang C Chew B Goodman A Rattner S Moody G Stetten P A Campochiaro D J Zack

The Wnt/frizzled cell signaling pathway has been implicated in the determination of polarity in a number of systems, including the Drosophila retina. The vertebrate retina develops from an undifferentiated neuroepithelium into an organized and laminated structure that demonstrates a high degree of polarity at both the tissue and cellular levels. In the process of searching for molecules that ar...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه زنجان - دانشکده علوم 1393

روش پلیمریزاسیون رادیکال آزاد یکی از پرکاربردترین روشهای مرسوم در صنعت است که از نوع زنجیری-رشد کننده میباشد. در این روش به علت وجود واکنشهای اختتام برگشتنا پذیر زنجیر، ماکرو مولکول هایی با توزیع وزن مولکولی پهن تولید می شوند که به سبب تأثیرپذیری شدید خواص پلیمر از درجه پلیمریزاسیون، رفتار پلیمر تولیدشده غیرقابل پیش بینی می باشد]1[. سنتز پلیمر ها به روش آنیونی امکان رسیدن به توزیع وزن مولکولی ب...

Journal: :Mechanisms of Development 2002
Michele R Illies Margaret T Peeler Anna Dechtiaruk Charles A Ettensohn

Wnt proteins and their receptors, members of the frizzled protein family, play a key role in regulating a wide range of developmental processes. Recently, putative regulators of Wnt signaling known as secreted frizzled-related proteins (SFRPs) have been identified in several vertebrates. Here, we describe the cloning of a novel SFRP (suSFRP1) from the sea urchin, Strongylocentrotus purpuratus. ...

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