Abstract Vascular inflammation activated by pro-inflammatory cytokines is an inflammatory response that occurs in the early stages of atherosclerosis. Endothelial dysfunction vascular begins with expression cell surface adhesion molecules cytokines. The purpose this study was to evaluate and verify effects isobavachalcone. In study, we investigated isobavachalcone on responses induced tumor nec...

Introduction  Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective:  We hypothesi...

Background: Cytokines are suggested to play a role in periodontitis. Objective: To determine and compare the levels of Interleukin-1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) samples amongst healthy individuals and  those with chronic periodontitis. Further to compare the GCF cytokine levels in three genotype classes defined by the respective gene p...

background: rheumatoid arthritis (ra) is a chronic multisystem autoimmune disease common in all races and ethnics. cytokines and cytokines receptors play an important role in ra pathogenesis and clinical presentation. objective: to investigate the serum levels of tnf-α, tnf-α ri, tnf-α rii and il-12 in ra patients and healthy control group. methods: in this study 43 patients fulfilling the revi...

TNFα is one of the inflammatory cytokines which plays an important role in activating the Caspase and inducing the apoptosis. This cytokine which is secreted in inflammations, induces the NO production in macrophages and leads to differentiation of the macrophages to the epithelioid and giant cells. One of the most important factors which stimulates the TNFα secretion, is LPS and th...