Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine, flavopiridol and SNS-032) with the ABCB1 transporter. Four o...

The sodium requirements, balance, excretion, patterns and composition of some pig tissues were studied in two feeding trials and a balance trial followed by an additional feeding period with terminal tissue composition analysis. The growth of pigs fed a corn-soybean meal diet without added salt was severely restricted. Results confirm that a sodium requirement of .09% of the diet is adequate an...

Different properties of quasars may be observed and analysed through the many ranges electromagnetic spectrum. Pioneering studies showed that an "H-R diagram" for was needed to organize these data, more than two dimensions were necessary: a four dimensional Eigenvector (4DE1) parameter space proposed. The 4DE1 makes use independent observational obtained from optical UV emission lines, as well ...

It is shown that R & D joint ventures make it more likely that firms will be able to sustain tacit product-market collusion, all else equal. JEL classification: LI3; 032