The biochemical and biological characteristics of CRM(197) are reviewed. Polysaccharide protein conjugate vaccines represent an important technological advancement that allowed for protection against dangerous diseases in vulnerable populations such as infants. The first carrier proteins, diphtheria and tetanus toxoids, were chosen in the context of an extensive body of information describing t...

Programmed cell death ligand-1 (PD-L1) has recently gained considerable attention for its role in tumor immune escape. Here, we identify a miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer (NSCLC), independent of immunoinhibitory signals. miR-197 is downregulated in platinum-resistant NSCLC specimens, resulting in the promotion of chemoresistance, tumorigen...

Abstract Socioeconomic factors influence patterns of care in colorectal cancer. Our study investigates the impact socioeconomic status (SES) on stage at presentation, receipt diagnostic imaging, treatment and overall survival (OS) a universal healthcare system. The Ontario Cancer Registry (OCR) was accessed to identify cohort patients diagnosed with adenocarcinoma from 2007 2016 Ontario, Canada...

Lung adenocarcinoma (LUAD) is a common cause of cancer-associated mortality. The dysregulation of microRNA (miR) expression has been reported to induce lung carcinogenesis. In the present study, miR‑197‑3p upregulation was detected within LUAD tissues compared with in adjacent noncancerous tissues. The suppression of miR‑197‑3p expression was confirmed to inhibit proliferative ability and induc...

The met proto-oncogene is functionally linked with tumorigenesis and metastatic progression. Validation of the receptor tyrosine kinase c-Met as a selective anticancer target has awaited the emergence of selective c-Met inhibitors. Herein, we report ARQ 197 as the first non-ATP-competitive small molecule that selectively targets the c-Met receptor tyrosine kinase. Exposure to ARQ 197 resulted i...

AMA Rogoziński M. Vitamin B12 supplementation in untreatable hiccup – case study. Medycyna Paliatywna/Palliative Medicine. 2022;14(4):197-200. doi:10.5114/pm.2022.127043. APA Rogoziński, (2022). Medicine, 14(4), 197-200. https://doi.org/10.5114/pm.2022.127043 Chicago Marek Stefan. 2022. "Vitamin study". Medicine 14 (4): Harvard pp.197-200. MLA study." vol. 14, no. 4, 2022, pp. Vancouver