Over the past two decades, the female hormone 17b-estradiol (estrogen) has emerged as an important contributor to energy homeostasis in both males and females. Early clinical evidence involved the observation that men lacking estrogen synthesis secondary to mutations in aromatase—the enzyme that converts androgen to estrogen—or men harboring estrogen resistance secondary to mutation of the estr...

Laser scanning provides a good means to collect information on forest stands. This paper presents an approach to delineate single trees automatically in small footprint light detection and ranging (lidar) data in deciduous and mixed temperate forests. In rasterized laser data possible tree tops are detected with a local maximum filter. Afterwards the crowns are delineated with a combination of ...

Nicotinic agonists elicit the release of dopamine from striatal synaptosomes by acting on presynaptic nicotinic acetylcholine receptors (nAChRs) on dopamine nerve terminals. Both a3b2* and a4b2 nAChR subtypes (but not a7* nAChRs) have been implicated. Here, we compared nAChR-evoked [H]dopamine release from rat striatal synaptosome and slice preparations by using the nicotinic agonist anatoxin-a...

Acute kidney injury (AKI) is a frequent clinical problem in critically ill patients and the associated mortality is high. Standard serum and urine biomarkers are insensitive and nonspecific for the detection of kidney injury in its early stages which limits the therapeutic options and may compromise the outcome. The study presents new candidates for biochemical markers of AKI, with potentially ...

Acute kidney injury (AKI) is a frequent clinical problem in critically ill patients and the associated mortality is high. Standard serum and urine biomarkers are insensitive and nonspecific for the detection of kidney injury in its early stages which limits the therapeutic options and may compromise the outcome. The study presents new candidates for biochemical markers of AKI, with potentially ...

An insertion grammar is based on pure rules of the form uu + lc~v (the string x is inserted in the context (u,u)). A strict subfamily of the context-sensitive family is obtained, incomparable with the family of linear languages. We prove here that each recursively enumerable language can be written as the weak coding of the image by an inverse morphism of a language generated by an insertion gr...

Acute kidney injury (AKI) is a frequent clinical problem in critically ill patients and the associated mortality is high. Standard serum and urine biomarkers are insensitive and nonspecific for the detection of kidney injury in its early stages which limits the therapeutic options and may compromise the outcome. The study presents new candidates for biochemical markers of AKI, with potentially ...

Acute kidney injury (AKI) is a frequent clinical problem in critically ill patients and the associated mortality is high. Standard serum and urine biomarkers are insensitive and nonspecific for the detection of kidney injury in its early stages which limits the therapeutic options and may compromise the outcome. The study presents new candidates for biochemical markers of AKI, with potentially ...

The discovery by Magendie of the sensory and motor functions of the dorsal and ventral roots of the spinal nerves provides an illuminating case study of the scientific and ethical considerations that arise when one contemplates restricting neurobehavioral research on animals because of the suffering it causes them. Such restrictions reduce the number of worthless experiments only at the cost of...

Acute kidney injury (AKI) is a frequent clinical problem in critically ill patients and the associated mortality is high. Standard serum and urine biomarkers are insensitive and nonspecific for the detection of kidney injury in its early stages which limits the therapeutic options and may compromise the outcome. The study presents new candidates for biochemical markers of AKI, with potentially ...