نتایج جستجو برای: 02 mgl

تعداد نتایج: 37076  

Journal: :Journal of virology 2010
Jacqueline P Upham Danielle Pickett Tatsuro Irimura E Margot Anders Patrick C Reading

Although sialic acid has long been recognized as the primary receptor determinant for attachment of influenza virus to host cells, the specific receptor molecules that mediate viral entry are not known for any cell type. For the infection of murine macrophages by influenza virus, our earlier study indicated involvement of a C-type lectin, the macrophage mannose receptor (MMR), in this process. ...

Journal: :Biochemical and biophysical research communications 2013
Sören V Siegmund Alexandra Wojtalla Monika Schlosser Andreas Zimmer Manfred V Singer

The endogenous cannabinoids anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG) are upregulated during liver fibrogenesis and selectively induce cell death in hepatic stellate cells (HSCs), the major fibrogenic cells in the liver, but not in hepatocytes. In contrast to HSCs, hepatocytes highly express the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) that pr...

Journal: :The Journal of pharmacology and experimental therapeutics 2017
Michael Z Leonard Shakiru O Alapafuja Lipin Ji Vidyanand G Shukla Yingpeng Liu Spyros P Nikas Alexandros Makriyannis Jack Bergman Brian D Kangas

An improved understanding of the endocannabinoid system has provided new avenues of drug discovery and development toward the management of pain and other behavioral maladies. Exogenous cannabinoid type 1 (CB1) receptor agonists such as Δ9-tetrahydrocannabinol are increasingly used for their medicinal actions; however, their utility is constrained by concern regarding abuse-related subjective e...

Journal: :The Journal of biological chemistry 1982
B Rotman R Guzman

Three genes (mglA, mglB, and mglC) required for active transport of substrate by the methylgalactoside permease were identified in a hybrid ColE1-DNA plasmid isolated from a clone (pLC3-14) of the Clarke-Carbon bank of Escherichia coli genes. A 4.6-kilobase DNA fragment obtained from pLC3-14 was cloned into the plasmid vector pBR322. The presence of the three mgl genes in the resultant plasmid,...

2017
Fabien Gay Karine Aguera Karine Sénéchal Angie Tainturier Willy Berlier Delphine Maucort-Boulch Jérôme Honnorat Françoise Horand Yann Godfrin Vanessa Bourgeaux

Erymet is a new therapy resulting from the encapsulation of a methionine gamma-lyase (MGL; EC number 4.4.1.11) in red blood cells (RBC). The aim of this study was to evaluate erymet potential efficacy in methionine (Met)-dependent cancers. We produced a highly purified MGL using a cGMP process, determined the pharmacokinetics/pharmacodynamics (PK/PD) properties of erymet in mice, and assessed i...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2008
Lusliany J Rondón Wouter M Tiel Groenestege Yves Rayssiguier Andrzej Mazur

The body maintains Mg(2+) homeostasis by renal and intestinal (re)absorption. However, the molecular mechanisms that mediate transepithelial Mg(2+) transport are largely unknown. Transient receptor potential melastatin 6 (TRPM6) was recently identified and shown to function in active epithelial Mg(2+) transport in intestine and kidney. To define the relationship between Mg(2+) status and TRPM6 ...

2009
Sandra J. van Vliet Liana Steeghs Sven C. M. Bruijns Medi M. Vaezirad Christian Snijders Blok Jésus A. Arenas Busto Marcel Deken Jos P. M. van Putten Yvette van Kooyk

Gonorrhea is one of the most prevalent sexually transmitted diseases in the world. A naturally occurring variation of the terminal carbohydrates on the lipooligosaccharide (LOS) molecule correlates with altered disease states. Here, we investigated the interaction of different stable gonoccocal LOS phenotypes with human dendritic cells and demonstrate that each variant targets a different set o...

2008
Mohd Sahaid Kalil Hisham Alshiyab Sahaid Kalil Aidil Abdul Hamid Wan Mohtar Wan Yusoff

This study was carried out to study the effect of trace metal addition for hydrogen production The results show that this bacterial need a selected nutrient with selected concentration. The optimum parameters for cultivation were at initial pH of 7.0 and temperature of 30°C. Trace metal addition to the new medium showed that only iron enhanced the H2 yield. The results showed that 25 mgL FeSO4⋅...

Journal: :Development 2011
Falko Riedel Daniela Vorkel Suzanne Eaton

The cuticular exoskeleton of arthropods is a composite material comprising well-separated layers that differ in function and molecular constituents. Epidermal cells secrete these layers sequentially, synthesizing components of distal cuticle layers before proximal ones. Could the order of synthesis and secretion be sufficient to account for the precision with which cuticle components localize t...

Journal: :Journal of plant physiology 2003
Sung Hun Park Jay L Morris Jung Eun Park Kendal D Hirschi Roberta H Smith

An efficient method to transform five cultivars of tomato (Lycopersicon esculentum), Micro-Tom, Red Cherry, Rubion, Piedmont, and E6203 is reported. A comparison was made of leaf, cotyledon, and hypocotyl explants on 7 different regeneration media without Agrobacterium tumefaciens cocultivation and on 11 different media with cocultivation. Although all cultivars and explants formed callus and r...

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