PURPOSE To investigate i.v. administration of delimotecan (MEN 4901/T-0128), a carboxymethyldextran polymer prodrug of the active camptothecin derivative T-2513, and to assess the maximum tolerated dose, safety profile, clinical pharmacology, and antitumor activity of delimotecan and metabolites. EXPERIMENTAL DESIGN Patients with solid tumors refractory to standard therapy received i.v. delim...

PURPOSE This study sought to determine whether the angiographic demonstration of slow antegrade contrast opacification of an occluded cerebral artery distal to the thrombus (clot outline sign) on cerebral arteriograms performed immediately before thrombolytic treatment is associated with higher recanalization rates relative to patients without antegrade contrast opacification distal to the occl...

Vaccination has become the most effective public health measure for the control of infectious diseases after the provision of clean drinking water. The history of vaccination is marked with great hopes and some disappointments. In particular, the second half of the 20th century witnessed the development of remarkable vaccination projects. There is a possibility that polio and measles may be era...

The NBS Boulder Laboratory is in the process of assembling a very high accuracy time transfer system. The system includes a 6.1 meter Ku-band satellite earth station, two transportable earth stations each with a 1.8 meter dish, and commercial modems designed for two-way timing. Elements of the facilities are described in this paper. High-accuracy timing with this equipment using the two-way tim...

It has long been possible to determine He/H ratios from radio or infrared recombination lines, making it possible to measure ionic abundance ratios for highly obscured emission-line objects. It is not possible to determine the total helium abundance from such data alone, however, since the ionization correction factor (ICF), the correction for unobservable stages of ionization of He or H, must ...

We report on single-dish monitoring and extremely high angular resolution observations of the flaring H2O megamaser in the Seyfert 2 galaxy Mrk 348. The H2O line is redshifted by ∼130 km s with respect to the systemic velocity, is very broad, with a FWHM of 130 km s, and has no detectable high velocity components within 1500 km s on either side of the strong line. Monitoring observations made w...

OH megamasers (OHMs) emit primarily in the main lines at 1667 and 1665 MHz, and differ from their Galactic counterparts due to their immense luminosities, large linewidths and 1667/1665 MHz flux ratios, which are always greater than one. We find that these maser properties result from strong 53 μm radiative pumping combined with line overlap effects caused by turbulent linewidths ∼ 20 km s; pum...

INTRODUCTION AND OBJECTIVES Circulating microRNAs (miRNA) are involved in the posttranscriptional regulation of genes associated with lipid metabolism (miRNA-33) and vascular function and angiogenesis (miRNA-126). The objective of this exploratory study was to measure plasma levels of miRNA-33 and miRNA-126 in patients with plaque psoriasis and evaluate their association with clinical parameter...