INTRODUCTION Premature ejaculation (PE) is defined as ejaculation within 1 minute (lifelong PE) or 3 minutes (acquired PE), inability to delay ejaculation, and negative personal consequences. Management includes behavioral and pharmacologic approaches. AIM To systematically review effectiveness, safety, and robustness of evidence for complementary and alternative medicine in managing PE. ME...

BACKGROUND The aim of this systematic review was to evaluate the efficacy and safety of liraglutide versus sitagliptin both in combination with metformin in patients with type 2 diabetes and provide reference basis for rational use of clinical drugs. METHODS Several databases were searched, including Web of science, PubMed, Cochrane library, CNKI, and Wanfang database. Only randomized control...

PURPOSE Considerable uncertainty exists regarding relative effects of allogeneic peripheral blood stem cells transplantation (PBSCT) versus bone marrow transplantation (BMT) on outcomes of patients with hematologic malignancies. PATIENTS AND METHODS To provide the totality of research evidence related to the effects of PBSCT versus BMT, we conducted an individual-patient data meta-analysis us...

BACKGROUND Major depression occurs in 4.4% to 20% of the general population. Studies suggest that major depression is accompanied by immune dysregulation and activation of the inflammatory response system (IRS). Our objective was to quantitatively summarize the data on concentrations of specific cytokines in patients diagnosed with a major depressive episode and controls. METHODS We performed...

OBJECTIVE Considering previous genetic studies on sudden infant death syndrome (SIDS) and the role of L/L serotonin transporter (5HTT) genotype and correlated genes monoamine oxidase A (MAOA) and dopamine transporter (DAT) in unexpected death, an investigation was carried out verifying their involvement in apparent life-threatening events (ALTE and idiopathic form [IALTE]), also assessing commo...

OBJECTIVE Although antipsychotics have been used empirically to prevent the development of postoperative delirium, there has been no confirming evidence to support their use. Thus, we conducted a systematic review and a meta-analysis to elucidate their efficacy and tolerability in surgical patients. DATA SOURCES MEDLINE, EMBASE, the Cochrane Library databases, CINAHL, and PsycINFO were search...

BACKGROUND Studies of anti-angiogenic agents (AAs), combined with chemotherapy (chemo) or as monotherapy in metastatic oesophago-gastric cancer (mOGC), have reported mixed outcomes. We undertook systematic review and meta-analysis to determine their overall benefits and harms. METHODS Randomized controlled trials in mOGC were sought investigating the addition of AAs to standard therapy (best ...

Objective: To describe the collaboration between Youth Justice New South Wales (YJNSW) and Health Forensic Mental Network (JHFMHN) during early COVID-19 Response (CR) across six centres in NSW, reduced incidence of self-harm noted over this period. Methods: Narrative article with analysis incident data initial CR period March to May 2020, compared same 2019. Results: During (March 2020), there ...

PURPOSE Reactions to contrast material are uncommon in diagnostic radiology, and vary in clinical presentation from urticaria to life-threatening anaphylaxis. Prior studies have demonstrated a high error rate in contrast reaction management, with smaller studies using simulation demonstrating variable data on effectiveness. We sought to assess the effectiveness of high-fidelity simulation in te...

Objectives. To compare reconstructive techniques, operative times, duration of hospitalization, and need for subsequent flap revisions between reconstructive approaches to lateral skull base defects. Study Design. Case series with chart review. Setting. Tertiary academic referral center. Subjects. Patients (n = 31) undergoing reconstruction of composite lateral skull base defects from 2002 to 2...