Renal cell carcinoma (RCC) is a common urological cancer worldwide and is known to have a high risk of metastasis, which is considered responsible for more than 90% of cancer associated deaths. Honokiol is a small-molecule biphenol isolated from Magnolia spp. bark and has been shown to be a potential anticancer agent involved in multiple facets of signal transduction. In this study, we demonstr...

To explore the possible mechanism of KiSS1 in control GnRH secretion participate in sexual development onset and normal reproduction regulation by investigate the changes of expression of KiSS1, GnRH in hypothalamus and LH, FSH, E2 in serum,by using RNA interference Mediated with Lentivirus-based Vectors, after Interfering expression of KiSS1. Constructed the eukaryotic expression plasmid of ra...

Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reprodu...

Kisspeptins (KP), peptide products of the kisspeptin-1 (KISS1) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISS1R). KISS1R couples to the Gαq/11 signaling pathway. KISS1 is a metastasis suppressor gene and the KP/KISS1R signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers. On the other hand, recent studies indicate that...

background: the kiss peptins and its receptor g protein coupled receptor (gpr54) or kiss1 receptor system are being described as key signaling molecules for reproductive function in animal models and humans. they play essential roles in regulation of the hypothalamic- pituitary- gonadal (hpg) axis and the onset of puberty and fertility. objective: this study was performed to delineate the assoc...

The progression of distant metastasis cascade is a multistep and complicated process, frequently leading to a poor prognosis in cancer patients. Recently, growing evidence has indicated that deregulation of microRNAs (miRNAs) contributes to tumorigenesis and tumor progression in colorectal cancer (CRC). In the present study, by comparing the miRNA expression profiles of CRC tissues and correspo...

Kisspeptins are well known as mediators of the coordinated communication between the brain-pituitary axis and the gonads in many vertebrates. To test the hypothesis that gonadal steroids regulate kiss1 and kiss2 mRNA expression in European sea bass (a teleost fish), we examined the brains of gonad-intact (control) and castrated animals, as well as castrated males (GDX) and ovariectomized female...

Several studies have shown that neuropeptide Y (NPY) is considered to be one of the key regulators of the hypothalamic-pituitary-gonadal axis in the mammals. Also, kisspeptin is a powerful upstream regulator of gonadotropin-releasing hormone neurons in the hypothalamus. The present study aims to investigate the effects of the intracerebroventricular (ICV) injection of NPY and BIBP3226 (NPY rece...

Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two discrete kisspeptin neuronal populations, which are sexually dimorphic and are believed to make distinct contributions to reproductive physiology. Within these kisspeptin neuron populations, Kiss1 expression is direc...

Kisspeptin is the product of the KISS1 (KiSS-1 metastasissuppressor) gene and is the ligand for the G-protein– coupled receptor, now known as the KISS1 receptor (KISS1R) (1 ). Both kisspeptin and KISS1R play a crucial role in the regulation of reproduction and puberty (1 ). The KISS1 gene encodes a precursor peptide of 145 amino acid residues, which undergoes proteolytic processing to generate ...