Polymyxin B (PMB) is a cationic cyclic decapeptide antibiotic with a fatty acyl (FA) modification at the α-amino group of Dab¹ (Dab: L-α,γ-diaminobutyric acid). In this study, which is part of a series of PMB structure-activity relationship investigations focused on identifying clinically useful peptide antibiotics, we synthesized ten des-FA PMB derivatives whose N-terminal moieties were change...

Our preceding report (24) dealt with the carcinogenicity of several polyfluoro derivatives of 4-dimethylaminoazobenzene (DAB) involving the equivalent positions of the prime ring (Chart 1). As in the case of the monofluoro derivatives (24, 26), all these compounds are more active carcino gens for the rat liver than the unsubstituted dye. These results are in great contrast to those ob tained af...

Two distinct glycogen phosphorylase inhibitors, 5-chloro-1H-indole-2-carboxylic acid [1-(4-fluorobenzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxoethyl]amide (CP-320,626) and 1,4-dideoxy-1,4-D-arabinitol (DAB), were characterized in vitro with respect to the influence of glucose on their potencies. CP-320,626 has previously been shown to bind to a newly characterized indole site, whereas DAB seems to ...

DC transmission grids are the promising electrical networks in near future especially with high penetration of large-scale renewables. This article proposes a modified version dual active bridge (DAB) dc/dc converter ac link capacitors generating reactive power to compensate for nonactive consumption, hence mitigating current stresses and losses improve efficiency. The proposed topology also en...

Abstract A hybrid system was designed and synthesized through reacting modified halloysite (Hal-Cl) with Schiff base (DAB-PC) applied as catalytic support for anchoring Pd NPs to afford Pd@Hal-DAB-PC catalyst. The resultant material well identified by various analyses including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), f...

Synchronization is the key part of OFDM receiver. A method to estimate Time Synchronization in DAB receiver is based on analysis of phase reference symbol is given. Synchronization analysis is performed under Rician channel with SNR 20dB and -8dB. Keyword: Fine time synchronization, phase reference symbol, OFDM and DAB.

In order to enhance efficiency in designing Digital Audio Broadcasting (DAB) transport network applications we combine Protocol Compiler-based high level design methods with the Atmel System Designer SoC development suite. We define DAB requirements and outline design as well as validation of a Ensemble Transport Interface Monitoring Unit (EMU). Experimental results and conclusions concerning t...

AIMS Lynch Syndrome is caused by mutations in DNA mismatch repair (MMR) genes. Mutation carrier identification is facilitated by immunohistochemical detection of the MMR proteins MHL1 and MSH2 in tumour tissue and is desirable as colonoscopic screening reduces mortality. However, protein detection by conventional immunohistochemistry (IHC) is subjective, and quantitative techniques are required...

Enzymes associated with the catabolism of 5-hydroxytryptophan (5-HT) were assayed in transplanted hepatomas, in primary lesions induced with 8'-methyl-4dimethylaminoazobenzene (St-Me-DAB), and in 8'-Me-DAB precancerous rat liver. Among six transplanted rat hepatomas, 5-HT decarboxylase activity was essentially absent in five, whereas the Morris hepatoma 51~8 manifested activity equivalent to th...

Field fires can modify soil nutrient cycling and alter microbial communities (SMC), although the latter is not well understood. In southern region of Puerto Rico, field have become a significant problem during dry season. To mimic effects fire, we performed prescribed on hillside at Juana Díaz Agricultural Experiment substation in October 2015 March 2017. A complete randomized block design was ...