Background: Micro RNAs (miRNAs) are a pivotal part of non-protein-coding endogenous small RNA molecules that regulate the genes involved in plant growth and development, and respond to biotic and abiotic environmental stresses posttranscriptionally.Objective: In the present study, we report the results of a systemic search for identifi cation of new miRNAs in B. rapa using homology-based ...

The plant-pathogen interaction is a multifactor process that may lead to resistance or susceptible responses of plant to pathogens. During the arms race between plant and pathogens, various biochemical, molecular and physiological events are triggered in plant cells such as ROS signaling, hormone activation and gene expression reprogramming. In plants, microRNAs (miRNAs) are key post-transcript...

•This study provides a quantitative map of 1,816 human pri-miRNA processing sites •Only 758 are confidently processed, while the majority non-canonical or false entries •We uncover atypical events such as alternative, nick, and inverse •SRSF3 is broad-acting cofactor modulating canonical pri-miRNAs Maturation microRNA (miRNA) initiated by DROSHA that cleaves primary transcript (pri-miRNA). More...

Background Macrophages play an important role in regulating the course of spinal tuberculosis within bone microenvironment. This study aimed to investigate differential expression miRNA macrophage-derived exosomes tuberculosis-infected microenvironment, identify miRNAs that hold potential as diagnostic markers and therapeutic targets. Methods We established cohorts for tuberculosis, collected m...

امروزه ورود به حوزه مدیریت کیفیت برای سازمان‌ها از اهمیت ویژه‌­ای برخوردار است. مدل­های تعالی سازمانی ابزاری است که را در این مسیر رهنمون می­‌کند. بدین منظور، ازجمله شبکه بانکی کشور، رویکردهای گوناگونی سازمان خود راستای تحقق ارزش‌های مدل­‌های استقرار می­کنند؛ اما محدودیت منابع موجود قبیل هزینه، نیروی انسانی، فرهنگ و غیره، تمامی رویکردها میسر نمی‌­سازد؛ ازاین‌رو مسئله اصلی کدام بیشترین تأثیر ارت...

Background: The goal of treatment for patients with RA is achieve to remission, or at least a state low disease activity. Exercise recommended in addition drug therapy. It has been found be effective greatly improving functionality and reducing cardiovascular risk without exacerbating Therefore, it that all should encouraged include aerobic resistant exercise training as part their routine (1)....

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cells, contributing to carcinogenesis tumour microenvironment. Recent studies have revealed that CAFs, normal cells all secrete exosomes contain miRNA, establishing cell-cell communication network within For example, miRNA dysregulation melanoma has been shown promote CAF activation via induction of e...

results treatments through mirnas can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. conclusions further work is needed to be done to make mirna treatments available to large number of people suffering from various bone diseases. context mirnas can regulate the expression of genes by interfering in their mrnas, acting as key regulators of diverse cell...