نتایج جستجو برای: ژن rab27a

تعداد نتایج: 16136  

2017
Joshua M. Boucher Ryan P. Clark Diana C. Chong Kathryn M. Citrin Lyndsay A. Wylie Victoria L. Bautch

Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. Here we show that dynamic regulation of mVEGFR1 stability and turnover in bloo...

2013
Angélique Bobrie Clotilde Théry

To understand the physiological functions of exosomes, we have recently used the inhibition of Rab27a, which prevents exosome release but also alters other secretion pathways. Our work demonstrates that the secretion of exosomes by some tumors in vivo can influence the immune microenvironment to promote tumor progression, but also that this phenomenon cannot be generalized to all tumors and all...

Journal: :The Biochemical journal 2005
Jennifer L Johnson Beverly A Ellis Deborah Noack Miguel C Seabra Sergio D Catz

Two of the major proteins secreted by the prostate epithelium secretory cells are PSA (prostate-specific antigen) and PSAP (prostatic-specific acid phosphatase). The molecules involved in the secretory machinery of PSA and PSAP, and the regulation of this machinery, remain unknown. In the present paper, we provide evidence that JFC1 [synaptotagmin-like protein (slp1)], a Rab27a- and PtdIns(3,4,...

Journal: :Journal of Cell Biology 2015

Journal: :Molecular Biology of the Cell 2004

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