نتایج جستجو برای: ژن pou1f1

تعداد نتایج: 15909  

2016
María Inés Pérez Millán Michelle L Brinkmeier Amanda H Mortensen Sally A Camper

Mutations in PROP1 are the most common cause of hypopituitarism in humans; therefore, unraveling its mechanism of action is highly relevant from a therapeutic perspective. Our current understanding of the role of PROP1 in the pituitary gland is limited to the repression and activation of the pituitary transcription factor genes Hesx1 and Pou1f1, respectively. To elucidate the comprehensive PROP...

Journal: :The Journal of clinical investigation 2011
Masaaki Yamamoto Genzo Iguchi Ryoko Takeno Yasuhiko Okimura Toshiaki Sano Michiko Takahashi Hitoshi Nishizawa Anastasia Evi Handayaningshi Hidenori Fukuoka Maya Tobita Takatoshi Saitoh Katsuyoshi Tojo Atsuko Mokubo Akio Morinobu Keiji Iida Hidesuke Kaji Susumu Seino Kazuo Chihara Yutaka Takahashi

The pituitary-specific transcriptional factor-1 (PIT-1, also known as POU1F1), is an essential factor for multiple hormone-secreting cell types. A genetic defect in the PIT-1 gene results in congenital growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiency. Here, we investigated 3 cases of adult-onset combined GH, PRL, and TSH deficiencies and found that the endo...

2016
Severine Van Hulle Margarita Craen Bert Callewaert Sjoerd Joustra Wilma Oostdijk Monique Losekoot Jan Maarten Wit Marc Olivier Turgeon Daniel J. Bernard Jean De Schepper

Immunoglobulin super family member 1 (IGSF1) deficiency syndrome is characterized by central hypothyroidism, delayed surge in testosterone during puberty, macro-orchidism, and in some cases, hypoprolactinemia and/or transient growth hormone (GH) deficiency. Our patient was a 19-year-old male adolescent who had been treated since the age of 9 years with GH and thyroxine for an idiopathic combine...

Journal: :The Journal of clinical investigation 1999
L E Cohen Y Hashimoto K Zanger F Wondisford S Radovick

Hypothalamic growth hormone-releasing hormone (GHRH) stimulates growth hormone (GH) gene expression in anterior pituitary somatotrophs by binding to the GHRH receptor, a G-protein-coupled transmembrane receptor, and by mediating a cAMP-mediated protein kinase A (PKA) signal-transduction pathway. Two nonclassical cAMP-response element motifs (CGTCA) are located at nucleotides -187/-183 (distal c...

2016
Zhongcheng Gao Kecheng Xue Lianfang Zhang Meng Wei

BACKGROUND The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) was reported to be associated with tumor progression and metastasis. The purpose of this study was to evaluate the prognostic value of Pit-1 in breast cancer patients. MATERIAL AND METHODS The relative expression levels of Pit-1 in breast cancer patients were detected by quantitative real-time PCR (qRT-PC...

2013
Toshihiro Tajima Katsura Ishizu Akie Nakamura

The pituitary gland produces hormones that play important roles in both the development and homeostasis of the body. Ontogeny of the anterior and posterior pituitary is orchestrated by inputs from neighboring tissues, cellular signaling molecules and transcription factors. Disruption of expression or function of these factors has been implicated in the etiology of combined pituitary hormone def...

2015
Xiaoyan Zhang Xianfeng Wu Wenchao Jia Chuanying Pan Xiangcheng Li Chuzhao Lei Hong Chen Xianyong Lan

The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammali...

2015
Nadia Schoenmakers Kyriaki S Alatzoglou V Krishna Chatterjee Mehul T Dattani

Central congenital hypothyroidism (CCH) may occur in isolation, or more frequently in combination with additional pituitary hormone deficits with or without associated extrapituitary abnormalities. Although uncommon, it may be more prevalent than previously thought, affecting up to 1:16 000 neonates in the Netherlands. Since TSH is not elevated, CCH will evade diagnosis in primary, TSH-based, C...

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