Introduction Pseudomonas aeruginosa has many mechanisms of resistance to fluoroquinolones. The main mechanism is to change the effect of two enzymes that open the DNA helix - the enzyme DNA gyrase (gyrA) and the topoisomerase IV (parC). In addition, mutations that render the MexAB-oprM pump (mexR) dysfunctional, leading to its overexpression, also enhance resistance to fluoroquinolones. In this...

J-PARC E70 experiment measures the missing-mass of Ξ hypernuclei ( 12 Be ) in Hadron Experimental Facility at J-PARC. We aim to reach best resolution 2 MeV/ c FWHM with a new magnetic spectrometer S-2S. The high-resolution spectroscopy will play an important role understand unknown ΞN interaction. start beginning 2023. This article presents preparation status.

We examined the response of Streptococcus pneumoniae 7785 to clinafloxacin, a novel C-8-substituted fluoroquinolone which is being developed as an antipneumococcal agent. Clinafloxacin was highly active against S. pneumoniae 7785 (MIC, 0.125 microg/ml), and neither gyrA nor parC quinolone resistance mutations alone had much effect on this activity. A combination of both mutations was needed to ...

OBJECTIVE To examine the number of food advertisements African American children are exposed to during children's television programming aired on predominantly African American and general television stations. DESIGN A content analysis was conducted to identify and analyze the health-related content (HRC) and physical activity-related content (PARC) of food advertisements shown during childre...

This work studies the performance of a cooperative network which consists of two channel-coded sources, multiple relays, and one destination. Due to spectral efficiency constraint, we assume only one time slot is dedicated for relaying. Conventional network coding based cooperation (NCC) selects the best relay which uses network coding to serve two sources simultaneously. The performance in ter...

OBJECTIVES Although the prevalence of fluoroquinolone resistance among methicillin-resistant Staphylococcus aureus (MRSA) is known to be higher than in methicillin-susceptible S. aureus (MSSA), the reasons have never been identified. METHODS We randomly selected 115 isolates of S. aureus collected from 10 different hospitals in Korea between June 2009 and May 2011. To investigate the differen...

Proper geometric and topological organization of DNA is essential for all chromosomal processes. Two classes of proteins play major roles in organizing chromosomes: condensin complexes and type II topoisomerases. In Escherichia coli, MukB, a structural maintenance of chromosome-like component of the bacterial condensin, and topoisomerase IV (Topo IV), a type II topoisomerase that decatenates th...

1 Laboratorio de Ciencias Biomédicas en Investigación Cĺınica (CBIC), Hospital Cĺınico Universitario de Valladolid, IECSCYL-SACYL, Avenida Ramón y Cajal 3, 47005 Valladolid, Spain 2 Critical Care Centre, Corporació Sanitària i Universitaria Parc Tauĺı—Hospital de Sabadell, Institut Universitari UAB Ciber Enfermedades Respiratorias, Parc Tauĺı 1, Sabadell, 08208 Barcelona, Spain 3 Department of ...

MENLO-PARC is a general purpose Monte Carlo program for calculating the next-toleading order O(a:) corrections to four-jet quantities in electron-positron annihilation. Any quantity which can be constructed out of the four jet momenta and which is insensitive to the quark helicities and the beam orientation can be computed. Both, virtual photon and 2 intermediate states (and y 2 interference) a...

This chapter deals with the PNA-assisted rare cleavage (PARC) of duplex DNA. The technique is a variety of the general ‘Achilles’ heel ́ cleavage strategy and uses PNA oligomers to protect very few sites on genomic DNA against enzymatic methylation. As a result, the PARC technique makes it possible to convert common restriction enzymes into a pool of infrequent genome cutters. These artificial g...