BACKGROUND: Primary surgery followed by platinum-taxane based chemotherapy has been the standard therapy in advanced ovarian cancer. However, the prognostic role of complete and so-called optimal and suboptimal debulking and its interaction with biological factors has not been not fully defined. METHODS: Exploratory analysis was conducted of 3 prospective randomized trials (AGO-OVAR 3, 5, and 7...

BACKGROUND AND METHODOLOGY Combined oral contraceptives (COCs) provide reliable and convenient contraception, although contraindications and tolerability issues may limit their use in some women. Progestogen-only pills (POPs) may be more suitable for some women, however, traditional POPs do not have the same contraceptive efficacy as COCs. A literature search was performed in order to assess th...

زمینه و هدف: کم‌تحرکی در مقابل آن تمرین جزء عوامل مرتبط با شاخص‌های آسیب کبدی به‌شمار می‌روند. وجود این هنوز نقش بسیاری از تمرین‌های ورزشی به‌ویژه تمرینات تناوبی مقاومتی مصرف برخی مکمل‌های غذایی جمله اسپیرولینا بر ایمنی التهابی کاملاٌ شناخته نشده است؛ بنابراین هدف پژوهش تعیین اثر هشت هفته مکمل‌دهی هوازی فعالیت بافت کبد بیان ژن CXCL1 عضلة موش‌های صحرایی نر بود.مواد روش‌ها: نیمه‌تجربی، 60 سر موش ن...

We have recently developed an in vitro assay for human tumor stem cells that permits cloning of human ovarian adenocarcinoma cells in soft agar. Tumor colonies grew from both effusions and biopsies from 85% of 31 ovarian cancer patients. The cloning efficiency did not vary with the histology of the tumor. Growth was induced with medium conditioned by the adherent spleen cells of mineral oil-pri...

We have recently developed an in vitro assay for human tumor stem cells that permits cloning of human ovarian adenocarcinoma cells in soft agar. Tumor colonies grew from both effusions and biopsies from 85% of 31 ovarian cancer patients. The cloning efficiency did not vary with the histology of the tumor. Growth was induced with medium conditioned by the adherent spleen cells of mineral oil-pri...

A second tumor suppressor locus on 17p that is distinct from 77*5.1has been identified in brain, breast, lung, and ovarian tumors. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCAI and OVCA2, that map to 17pl3.3. The two genes are ubiquitously expressed and encode proteins of 443 and 227 amino acids, respectively, ...

facilitates apoptosis by targeting several anti-apoptotic genes. If miR-466h-5p activation is demonstrated to be a universal early response in apoptotic pathways in CHO, 2 Mü ller, D. et al. (2008) MicroRNAs as targets for engineering of CHO cell factories. Trends Biotechnol. 26, 359–365 3 Xu, X. et al. (2011) The genomic sequence of the Chinese hamster ovar (CHO)-K1 cell line. Nat. Biotechnol....

Computational models are commonplace in engineering gelds. The predictive ability of such models can bs improved by tuning them to experimental data. To that extent, the user must consider if the dynamics model possess the capacity to represent the dominant physics in the system. A pseudo dynamic stiffness finite element model will be used to rep-t the dynamics of the harmonically forced system...

Lonidamine is a dechlorinated derivative of indazole-3-carboxylic acid which preclinically synergizes with hyperthermia. Clinically, this nonmyelosuppressive drug (given p.o. daily) is active as a single agent in a variety of malignancies. On this basis, a Phase I study which incorporates a drug escalation schema as well as an escalation in temperature, i.e., 41.0°Cfor 85 min to 41.8°Cfor 75 ...