نتایج جستجو برای: ژن he4
تعداد نتایج: 16408 فیلتر نتایج به سال:
results: the only significant difference was the older age of the malignant group vs. benign group (p = 0.001) regarding demographic findings. as concerns the clinical symptoms, presence of abdominal discomfort in pre-diagnosis period was the only significant parameter in malignant group (p = 0.001). additionally, data analysis of patients as a total group showed that specificity (96.4%), posit...
After 10 months of continuous cultivation in vitro, two cell lines (HE3-2 and HE4-2 cell lines) of embryonic tissue origin from Syrian hamsters did not produce tumors upon subcutaneous implantation into the hosts. After 13 months, however, the similar implantation resulted in the development of rapidly growing transplantable fibrosarcomas. The tumor-producing capacity of HE3-2 cell line was hig...
The best available marker for epithelial ovarian cancer is still considered to be CA-125 due to a combination of reliability and general availability. HE4 is more sensitive than specific than CA-125, however the former is not in routine use. NICE still therefore recommends CA-125 rather than HE4. CA-125 is used for the diagnosis of epithelial ovarian cancer. αFP and βHCG are useful for identify...
Introduction Many women with benign pelvic masses, suspected of ovarian cancer, are unnecessarily referred for treatment at specialized centers. There is an unmet clinical need to improve diagnostic assessment in these patients. Our objective was obtain summary estimates the accuracy human epididymis protein (HE4) diagnosing cancer and compare performance HE4 that antigen 125 (CA125). Material ...
The magnetic particles have a significant influence on the immunoassay detection and cancer therapy. Herein, the chemiluminescence immunoassay combined with the magnetic particles (MPCLIA) was presented for the clinical determination and analysis of human epididymis protein 4 (HE4) in the human serum. Under the optimized experiment conditions, the secure MPCLIA method can detect HE4 in the broa...
OBJECTIVE: The objective of this study was to explore the combined usage of human epididymis protein 4 (HE4) and CA 125 to help the diagnosis and differentiating malignant pelvic masses from benign diseases. METHOD: This was a multicenter clinical study and nine hospitals had been involved and totally 779 patients with pelvic mass have been enrolled. The pathologic diagnosis confirmed that 288 ...
Analysis of falsely elevated risk of ovarian malignancy algorithm in women with ovarian endometrioma
OBJECTIVE To estimate the incidence of falsely elevated risk of ovarian malignancy algorithm (ROMA) in a group of women with pathologically confirmed endometrioma and to investigate the associated factors. METHODS One hundred premenopausal women surgically diagnosed with ovarian endometrioma were selected. Preoperative clinical, laboratory, and surgical characteristics were compared between t...
OBJECTIVES The aim of the study was to assess the role of HE4 and CA125 in differentiation between malignant and non-malignant endometrial pathologies. MATERIAL AND METHODS A retrospective study of 87 patients with endometrial pathologies was conducted. Tumor markers were assessed two weeks before surgical intervention in each subject. The final diagnosis was established on the basis of the h...
PURPOSE Efforts to validate ovarian cancer early detection biomarkers with immunoassays are challenged by the limited specimen volumes available. We sought to develop a specimen-efficient assay to measure CA125 in serum, assess its reproducibility, validity, and performance, and test its potential for multiplexing and combining with human epididymis protein 4 (HE4), a promising novel ovarian ca...
OBJECTIVE Recently, 14-3-3 zeta protein was identified as a potential serum biomarker of epithelial ovarian cancer (EOC). The goal of this study was to investigate the clinical potential of 14-3-3 zeta protein for monitoring EOC progression compared with CA-125 and HE4. DESIGN Prospective follow-up study. SETTING University of Pecs Medical Center Department of Obstetrics and Gynecology/Onco...
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