RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific RORα 'gain of function' mouse model under the control of the fatty acid binding protein 4 (FABP4) promoter to elucidate the function of RORα in adipose tissue. The Tg-FABP...

Degree of unsaturation of fatty acids, which is influenced by lipid source and level of metabolism in the rumen, is a major determinant in how dietary lipids affect genes that regulate beef marbling. A total of 28 Red Norte bulls with an initial live weight of 361±32 kg (P>0.05) were used in a completely randomized experimental design to analyze the expression of genes that are involved in lipi...

Skin resident memory T cells (TRM) are a subset of which reside in skin for long term. They require exogenous free fatty acid their survival, and fatty-acid binding protein 4 (FABP4) 5 (FABP5) considered to take part lipid uptake. However, the detailed relation FABP4 with TRM function is still unknown. Here, we analyzed role development functional activities murine contact hypersensitivity mode...

Abstract Background and Aims FABP4, a fatty acid-binding protein, is predominantly expressed in adipose tissue (AT) has been shown to be elevated patients with chronic kidney disease (CKD). Although levels of FABP4 have linked cardiovascular end-stage renal (ESRD) patients, the cause this increase unclear. The aim study was evaluate expression AT under uremic conditions its impact on function m...

The purpose of the present study was to identify histological biomarkers that could be used predict adipose tissue invasion by oral squamous cell carcinoma (OSCC). medical records and preoperative computed tomography scans patients with primary OSCC suspected buccal fat pad were retrospectively reviewed, an immunohistochemical candidate predictive (α-SMA, E-cadherin, N-cadherin, FABP4, Col VI, ...

s and Commentaries: A new link between obesity and heart disease Danielle Feuvray University of Paris-Sud 11 and CNRS UMR 8162, Marie Lannelongue Hospital, Le Plessis Robinson, France Correspondence: Danielle Feuvray, University of Paris-Sud 11 and CNRS UMR 8162, Marie Lannelongue Hospital, 92350 Le Plessis Robinson, France. e-mail: [email protected] Conflicts of interest: None. Adipoc...

In the present study cytogenetic localization of eight fatty acid binding protein genes in the pig genome was shown. BAC clones, containing sequences of selected genes (FABP1, FABP2, FABP3, FABP4, FABP5, FABP6, FABP7 and FABP8) were derived from porcine BAC libraries and mapped by FISH to porcine chromosomes (SSC) 3q12, 8q25, 6q26, 4q12, 4q12, 16q22, 1p22 and 4q12, respectively. Detailed analys...

Purpose: Residual disease following primary cytoreduction is associated with adverse overall survival in patients with epithelial ovarian cancer. Accurate identification of patients at high risk of residual disease has been elusive, lacking external validity and prompting many to undergo unnecessary surgical exploration. Our goal was to identify and validate molecular markers associated with hi...

BACKGROUND Type 1 diabetes mellitus is associated with a high risk for early atherosclerotic complications. Altered lipids and lipoprotein metabolism in chronic diabetes mellitus is associated with pathogenesis of atherosclerosis and other cardiovascular diseases. The aim of this study was to investigate the effects of 4 weeks resistance training on plasma lipid profile, fatty acid binding prot...