The gonad arms of C. elegans hermaphrodites acquire invariant shapes by guided migrations of distal tip cells (DTCs), which occur in three phases that differ in the direction and basement membrane substrata used for movement. We found that mig-6 encodes long (MIG-6L) and short (MIG-6S) isoforms of the extracellular matrix protein papilin, each required for distinct aspects of DTC migration. Bot...

Parkinson’s disease (PD) is a progressive neurodegenerative disorder mainly characterized by movement dysfunction. Earlier, it was found that (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol (Prottremin) demonstrated antiparkinsonian activity in vivo on different animal models of PD. The paper presents synthesis new Prottremin derivative, (1R,2R,6S)-2(4-(4-isopropylbenzyl)piperazin...

Coxiella burnetii, an obligate intracellular bacterial pathogen that causes Q fever, undergoes a biphasic developmental cycle that alternates between a metabolically-active large cell variant (LCV) and a dormant small cell variant (SCV). As such, the bacterium undoubtedly employs complex modes of regulating its lifecycle, metabolism and pathogenesis. Small RNAs (sRNAs) have been shown to play i...

We report experimental rate coefficients for the energy-pooling collisions K(4PJ)1K(4PJ)→K(4S) 1K(nl) with product states nl55P , 6S , and 4D . The experimental procedure and analysis are similar to those used in a recent study of energy-pooling collisions in cesium. In potassium, it was found that 4P1/2 14P1/2 collisions are more efficient than 4P3/214P3/2 collisions for populating 5P , while ...

For fixed s 1 and t1,t2 ∈ (0,1/2) we prove that the inequalities G(t1a + (1− t1)b,t1b+(1− t1)a)A1−s(a,b) > AG(a,b) and G(t2a+(1− t2)b,t2b+(1− t2)a)A1−s(a,b) > L(a,b) hold for all a,b > 0 with a = b if and only if t1 1/2− √ 2s/(4s) and t2 1/2− √ 6s/(6s) . Here G(a,b) , L(a,b) , A(a,b) and AG(a,b) are the geometric, logarithmic, arithmetic and arithmetic-geometric means of a and b , respectively....

to the hospitals in their districts in return for the hospital service rendered to their employees, as many large firms are in the habit of doing. It was decided to ask the Ministry of Health to make this suggestion to the Corporations. Many Lancashire hospitals were found to be asking non-contributing patients to pay from 6s. a day downwards, and an hospital of seventy beds has received ?2,000...

A precision polarimeter has been developed to measure the linear polarization degree of Rayleigh scattered light. Application is made to measurement of the linear depolarization spectrum of atomic Cs in the vicinity of the 6s S1/2→6p P j resonance transition. For measurements in an ;220 cm range around the 6s S1/2→6p P3/2 resonance transition, the ratio of line strengths for the two resonance t...

Three megastigmane derivatives, (6R, 7Z)-9,10-dihydroxy-4,7-megastigmadien-3-one, (6S,7E)-6,9,10trihydroxy-4,7-megastigmadien-3-one 6-O-β-D-glucopyranoside and (5R, 6S, 7E)-6, 9, 10-trihydroxy-7megastigmane-3-one 9-O-β-D-glucopyranoside, along with fourteen known compounds, were isolated from an ethanolic extract of Cissus quadrangularis Linn. The structures of the megastigmane derivatives were...