The Green Revolution dwarfing genes, Rht-B1b and Rht-D1b, encode mutant forms of DELLA proteins and are present in most modern wheat varieties. DELLA proteins have been implicated in the response to biotic stress in the model plant, Arabidopsis thaliana. Using defined wheat Rht near-isogenic lines and barley Sln1 gain of function (GoF) and loss of function (LoF) lines, the role of DELLA in resp...

The effect of five fertilizers; NPK (15-15-15), organo-chemical hormone mixed formula 1 (HO-1), Formula 2 (HO-2), 3 (HO-3) and granular organic fertilizer (GOF) were investigated on maize yield soil properties in a Randomized Complete Block Design with 4 replications. new hybrid (GT 822) was sown at 75 x 25 cm² spacing. rate 300 kg ha-1. Initial analysis showed that the had lower nutrients but ...

Parametric techniques commonly rely on specific distributional assumptions. It is therefore fundamental to preliminarily identify the eventual violations of such Therefore, appropriate testing procedures are required for this purpose deal with a goodness-of-fit (GoF) problem. This task can be quite challenging, especially small sample sizes and multivariate data. Previous studiesshowed how GoF ...

Effective and efficient representation of color features of multiple video frames or pictures is an important yet challenging task for visual information management systems. Key frame-based methods to represent the color features of a group of frames (GoF) are highly dependent on the selection criterion of the representative frame(s), and may lead to unreliable results. We present various histo...

TRPML3 belongs to the TRPML subfamily of the transient receptor potential (TRP) channels. The A419P mutation in TRPML3 causes the varitint-waddler phenotype as a result of gain-of-function mutation (GOF). Regulation of the channels and the mechanism by which the A419P mutation leads to GOF are not known. We report here that TRPML3 is a Ca(2+)-permeable channel with a unique form of regulation b...

The 1977-1978 influenza epidemic was probably not a natural event, as the genetic sequence of the virus was nearly identical to the sequences of decades-old strains. While there are several hypotheses that could explain its origin, the possibility that the 1977 epidemic resulted from a laboratory accident has recently gained popularity in discussions about the biosafety risks of gain-of-functio...

BACKGROUND Gain-of-function (GOF) mutations in the human signal transducer and activator of transcription 1 (STAT1) manifest in immunodeficiency and autoimmunity with impaired TH17 cell differentiation and exaggerated responsiveness to type I and II interferons. Allogeneic bone marrow transplantation has been attempted in severely affected patients, but outcomes have been poor. OBJECTIVE We s...

Well-performed Video quality assessment (VQA) method should be consistent with human visual systems for better prediction accuracy. In this paper, we propose a VQA method using motion-compensated temporal filtering (MCTF) and manifold feature similarity. To be more specific, a group of frames (GoF) is first decomposed into a temporal high-pass component (HPC) and a temporal low-pass component (...

Mutations of the p53 gene hallmark many human cancers. Several p53 mutant proteins acquire the capability to promote cancer progression and metastasis, a phenomenon defined as Gain of Oncogenic Function (GOF). The downstream targets by which GOF p53 mutants perturb cellular programs relevant to oncogenesis are only partially known. We have previously demonstrated that SLC25A1 (CIC) promotes tum...

BACKGROUND Genetic causes of exaggerated or reduced pain sensitivity in humans are well known. Recently, single nucleotide polymorphisms (SNPs) in the gene P2RX7, coding for the ATP-gated ion channel P2X7, have been described that cause gain-of-function (GOF) and loss-of-function (LOF), respectively of this channel. Importantly, P2RX7 SNPs have been associated with more or less severe pain scor...