OBJECTIVE The goal of this study was to compare the analgesic effect of sucrose with that of the combination of sucrose and the local anesthetic cream EMLA during venipuncture in preterm neonates. METHODS This randomized, double-blind prospective study included infants younger than 37 weeks' gestational age during 1 routine venipuncture for blood sampling. Each child randomly received either ...

conclusions although the results of this study showed superiority of application of emla cream as a topical anesthetic for pain relief of blood sampling, both lidocaine 5% and benzocaine 5% offer considerable efficacy in pain relief of venipuncture. results at the end of study, the emla products (a and b) caused a significant decrease in pain (p < 0.05) in comparison with the products c (lidoca...

PURPOSE Transrectal ultrasound-guided prostate biopsy is the procedure of choice for diagnosing prostate cancer. We compared with pain-relieving effect of acetaminophen, a known drug for enhancing the pain-relieving effect of tramadol, and eutectic mixture of local anesthetics (EMLA), a local anesthetic agent, with that of the conventional periprostatic nerve block method. MATERIALS AND METHO...

The development of topical anesthetics has provided the family physician with multiple options in anesthetizing open and intact skin. The combination of tetracaine, adrenaline (epinephrine), and cocaine, better known as TAC, was the first topical agent available for analgesia of lacerations to the face and scalp. Cocaine has been replaced with lidocaine in a newer formulation called LET (lidoca...

PURPOSE This study compared the efficacy of commonly used topical anesthetics using an objective measuring scale. METHODS The following were tested: 5% EMLA cream, 10% cocaine, 10% lidocaine, 10% benzocaine, 1% dyclonine, and a placebo. A special instrument was designed to serve the purpose of pressure application on the gingiva to obtain a threshold discomfort level in grams before and after...

Pain relief may be improved by reducing sensitization of nociceptive pathways caused by tissue injury. Such a reduction depends mainly on inhibition of local inflammatory changes and the relation between duration of nociceptive block and nociceptive input. In this study we examined if prolonged topical treatment with local anaesthetics could reduce late hyperalgesia and local inflammation after...

abstract background the present randomized clinical trial evaluated the efficacy of a topical lidocaine-prilocaine cream (emla) to relief pain during spinal puncture in pediatric oncology patients. materials and methods sixty patients with malignancy candidate for spinal puncture were selected for this study. the patients were randomly allocated to two groups. group a had topical emla cream and...

Background. Untreated immunization pain causes undue distress and contributes to underimmunization through physician, and possibly parental, resistance to multiple simultaneous injections. Objective. To compare the efficacies of two pain management methods in reducing immediate immunization injection pain and distress in school-aged children. Design. A randomized, controlled clinical trial of e...

BACKGROUND To alleviate stinging pain in the skin entry area and visceral discomfort in patients who are undergoing ESWL. OBJECTIVES This study was designed to investigate the effectiveness of the EMLA cream in combination with remifentanil patient-controlled analgesia (PCA) in patients undergoing ESWL treatment. PATIENTS AND METHODS Sixty patients were divided into two double-blind randomi...