BACKGROUND A series of studies have been conducted to evaluate the associations between vitamin D receptor (VDR) and aggrecan variable numbers of tandem repeat (VNTR) polymorphisms and the risk of intervertebral disc degeneration (IDD), but produced conflicting results. OBJECTIVE we performed a meta-analysis to address a more accurate estimation of the associations between the above gene poly...

Calcitriol [1,25(OH)2D3], the hormonal derivative of vitamin D3, is an antiproliferative and prodifferentiation factor for several cell types, including cultured melanocytes and malignant melanoma (MM) cells. Several polymorphisms of the vitamin D receptor (VDR) gene have been described including a FokI RFLP in exon 2, BsmI, and ApaI polymorphisms in intron 8 and an adjacent TaqI RFLP in exon 9...

Annotation. Breast cancer is the most common diagnosed in women. In last 5 years, it has been 7.8 million women, and 2020, 685,000 deaths from breast were registered. The growing number of patients with this pathology cost therapy creates a need to study new methods diagnosis treatment. Therefore, detailed attention paid genetic risk factors for cancer, particular, VDR gene its polymorphisms Ap...

The vitamin D receptor (VDR) gene has been associated with prostate cancer, although previous results are somewhat equivocal. To further study this, we did a family-based case-control study (N = 918) of the association between prostate cancer and six common VDR variants: Cdx2, FokI, BsmI, ApaI, TaqI , and the poly-A microsatellite. Looking at each variant alone, only FokI and ApaI were associat...

BACKGROUND Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of vitamin D levels, its metabolism, and VDR polymorphism with various ...

Vitamin D (VD) is implicated in multiple aspects of human physiology and vitamin D receptor (VDR) polymorphisms are associated with a variety of neuropsychiatric disorders. Although VD deficiency is highly prevalent in epilepsy patients and converging evidence indicates a role for VD in the development of epilepsy, no data is available on the possible relationship between epilepsy and genetic v...

FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) no...

Background: Recurrent spontaneous abortion (RSA) is a frequent reproductive problem, with three or more abortions affecting 1 to 2%, two or more abortions affecting up to 5% of women of reproductive age. Some polymorphisms are supposed to be etiology in this group.Vitamin D receptor (VDR) gene polymorphism seems to be a good ones to be searched due to their function on placenta. Materials and M...

BACKGROUND In patients with advanced non-small-cell lung cancer, vitamin D receptor (VDR) polymorphisms and haplotypes are reported to be associated with survival. We hypothesized that a similar association would be observed in patients with head and neck squamous-cell carcinoma (HNSCC). METHODS In a post-hoc analysis of our previous prospective cohort study, VDR polymorphisms including Cdx2 ...